FMOC-assisted synthesis of a 29-residue cystine-knot trypsin inhibitor containing a guaninyl amino acid at the P1-position

被引：16

作者：

Avrutina, O

Schmoldt, HU

Kolmar, H

Diederichsen, U

机构：

[1] Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] Inst Mikrobiol & Genet, Abt Mol Genet, D-37077 Gottingen, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 2004卷 / 23期

关键词：

cyclotides; amino acids; protein mimetics; solid-phase synthesis; trypsin inhibitors;

D O I：

10.1002/ejoc.200400440

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An Fmoc-assisted synthesis of a 29 amino acid trypsin inhibitor (McoTI-29) is presented, which contains a non-natural guaninyl nucleo amino acid as arginine mimetic at the P1 position. This artificial amino acid functions as a conformational restricted arginine isoster with reduced basicity. The folded cyclotide McoTI-II open-chain variant McoTI-29 has been synthesized from a linear precursor by in situ oxidation. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004)

引用

页码：4931 / 4935

页数：5

共 23 条

[1]

*ABI, ABI 433A PEPT SYNTH

[2]

*ABI, ABI 433 A PEPT SYNTH

[3]

ALBERICIO F, 2000, FMOC SOLID PHASE PEP, P81

[4]

CHAN WC, 2000, FMOC SOLID PHASE PEP, P63