Bivalirudin monitored with the ecarin clotting time for anticoagulation during cardiopulmonary bypass

被引：58

作者：

Koster, A

Chew, D

Gründel, M

Bauer, M

Kuppe, H

Spiess, BD

机构：

[1] Deutsch Herzzentrum Berlin, Dept Anesthesia, D-13353 Berlin, Germany

[2] Flinders Med Ctr, Dept Cardiol, Bedford Pk, SA, Australia

[3] Deutsch Herzzentrum Berlin, Dept Thorac & Cardiovasc Surg, D-13353 Berlin, Germany

[4] Virginia Commonwealth Univ, Dept Cardiothorac Anesthesia, Richmond, VA USA

来源：

ANESTHESIA AND ANALGESIA | 2003年 / 96卷 / 02期

关键词：

D O I：

10.1097/00000539-200302000-00015

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Bivalirudin, a new short-acting direct thrombin inhibitor, provides an elimination mechanism independent of specific organ function. We successfully used this new drug, monitored at the point of care via the ecarin clotting time, for anticoagulation during cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia heparin allergy and impaired renal function.

引用

收藏

页码：383 / 386

页数：4

相关论文

共 8 条

[1] The Particulate Whodunit: Introductory remarks for integrative summary session [J].

Bates, DV .

INHALATION TOXICOLOGY, 2000, 12 :1-2

[2] Recombinant hirudin as an alternative for anticoagulation during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II: A 1-year experience in 57 patients [J].

Koster, A ;

Hansen, R ;

Kuppe, H ;

Hetzer, R ;

Crystal, GJ ;

Mertzlufft, F .

JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA, 2000, 14 (03) :243-248

[3]

Koster A, 2000, J CARDIOTHOR VASC AN, V14, P249

[4] The plasma supplemented modified activated clotting time for monitoring of heparinization during cardiopulmonary bypass: A pilot investigation [J].

Koster, A ;

Despotis, G ;

Gruendel, M ;

Fischer, T ;

Praus, M ;

Kuppe, H ;

Levy, JH .

ANESTHESIA AND ANALGESIA, 2002, 95 (01) :26-30

[5] One-year experience with the platelet glycoprotein IIb/IIIa antagonist tirofiban and heparin during cardiopulmonary bypass in patients with heparin-induced thrombocytopenia type II [J].

Koster, A ;

Meyer, O ;

Fischer, T ;

Kukucka, M ;

Krabatsch, T ;

Bauer, M ;

Kuppe, H ;

Hetzer, R .

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 2001, 122 (06) :1254-1255

[6] Monitoring hirudin anticoagulation in two patients undergoing cardiac surgery with a plasma-modified act method [J].

McDonald, SB ;

Kattapurum, BM ;

Saleem, R ;

Joist, HJ ;

Avidan, M ;

Despotis, GJ .

ANESTHESIOLOGY, 2002, 97 (02) :509-512

[7] Use of heparin during cardiopulmonary bypass in patients with a history of heparin-induced thrombocytopenia [J].

Pötzsch, B ;

Klóvekorn, W ;

Madlener, K .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 343 (07) :515-515

[8]

Potzsch B, 1997, THROMB HAEMOSTASIS, V77, P920