Emergence of complex and diverse CRF02-AG/CRF06-cpx recombinant HIV type 1 strains in Niger, West Africa

被引：24

作者：

Mamadou, S

Vidal, N

Montavon, C

Ben, A

Djibo, A

Rabiou, S

Soga, G

Delaporte, E

Mboup, S

Peeters, M

机构：

[1] IRD, Retrovirus Lab, UR 36, F-34394 Montpellier 5, France

[2] Univ Montpellier 1, Montpellier, France

[3] Natl Hosp, Niamey, Niger

[4] CHI Le Dantec, Lab Bacteriol Virol, Dakar, Senegal

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 2003年 / 19卷 / 01期

关键词：

D O I：

10.1089/08892220360474005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

On the basis of partial env and gag subtyping, we documented that the majority of HIV-1 strains circulating in Niger were CRF02-AG (54.3%) or CRF06-cpx (18.1%) and that 9% of the samples were possible recombinants between CRF02 and CRF06. To determine in more detail the precise structure of these viruses we sequenced the full-length genomes for three such strains (97NE-003, 00NE-036, and 00NE-095). From the bootscan and phylogenetic tree analysis it is evident that the new viruses are the result of recombination events between CRF02-AG and CRF06-cpx strains. Importantly, each virus had a different complex recombinant structure with multiple breakpoints, leading to viruses with complex mosaic patterns.

引用

页码：77 / 82

页数：6

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