Mitsunobu type C-N bond formation with 4,7-dimethyl-3,5,7-hexahydro-1,2,4,7-tetrazocin-3,8-dione (DHTD), a new cyclic azodicarboxamide

被引：9

作者：

Tsunoda, T ^{[1
]}

Kawamura, Y ^{[1
]}

Uemoto, K ^{[1
]}

Ito, S ^{[1
]}

机构：

[1] Univ Tokushima, Fac Pharmaceut Sci, Tokushima 770, Japan

来源：

HETEROCYCLES | 1998年 / 47卷 / 01期

关键词：

D O I：

10.3987/COM-97-S(N)78

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The combination of 4,7-dimethyl-3,5,7-hexahydro-1,2,4,7-tetrazocin-3,8-dione (DHTD) and tributylphosphine (TBP) was found to mediate successfully C-N bond formation between N-methyltosylamide, a typical N-nucleophile, and several alcohols of different structural types. The unique feature of this combination is that it activates the reaction of sec-alcohols at room temperature.

引用

页码：177 / 179

页数：3

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