Citrus flavonoids:: Molecular structure, biological activity and nutritional properties:: A review

被引:790
作者
Tripoli, Elisa [1 ]
La Guardia, Maurizio [1 ]
Giammanco, Santo [1 ]
Di Majo, Danila [1 ]
Giammanco, Marco [1 ]
机构
[1] Univ Palermo, Div Physiol & Human Nutr, Dept Med Pneumol Physiol & Human Nutr, I-90127 Palermo, Italy
关键词
citrus fruits; flavonoids; antioxidant; atherosclerosis; cancer; ANTIOXIDANT ACTIVITY RELATIONSHIPS; JUICE-DRUG-INTERACTIONS; ESTROGEN BINDING-SITES; CORONARY HEART-DISEASE; PROSTATE-CANCER CELLS; CHOLESTEROL-FED RATS; GRAPEFRUIT JUICE; FLAVANONE GLYCOSIDES; POLYMETHOXYLATED FLAVONES; LIQUID-CHROMATOGRAPHY;
D O I
10.1016/j.foodchem.2006.11.054
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Epidemiological studies have shown an inverse relationship between dietary flavonoid intakes and cardiovascular diseases. Citrus fruits are the main winter fruits consumed in the Mediterranean diet, so they are the main source of dietary flavonoids. The possible beneficial effects are due, not only to the high amounts of vitamins and minerals, but also to the antioxidant properties of their flavonoids. Dietary flavonoids may help to supplement the body antioxidant defences against free radicals. These compounds' possible beneficial effects are due to their antioxidant activity, which is related to the development of atherosclerosis and cancer, and to antiinflammatory and antimicrobial activity. The present review summarizes the existing bibliography on biological and pharmacological studies of Citrus flavonoids, both in vitro and in vivo. (C) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:466 / 479
页数:14
相关论文
共 126 条
[11]   Antioxidant activity and phenolic composition of citrus peel and seed extracts [J].
Bocco, A ;
Cuvelier, ME ;
Richard, H ;
Berset, C .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 1998, 46 (06) :2123-2129
[12]  
BOMBARDELLI E, 1993, CHIMICAOGGI, P25
[13]  
BORS W, 1990, METHOD ENZYMOL, V186, P343
[14]  
BORS W, 1990, ANTIOXIDANTS THERAPY, V1, P165
[15]   EFFECT OF CATECHINS AND CITRUS FLAVONOIDS ON INVASION INVITRO [J].
BRACKE, M ;
VYNCKE, B ;
OPDENAKKER, G ;
FOIDART, JM ;
DEPESTEL, G ;
MAREEL, M .
CLINICAL & EXPERIMENTAL METASTASIS, 1991, 9 (01) :13-25
[16]   THE FLAVONOID TANGERETIN INHIBITS INVASION OF MO4 MOUSE CELLS INTO EMBRYONIC CHICK HEART INVITRO [J].
BRACKE, ME ;
VYNCKE, BM ;
VANLAREBEKE, NA ;
BRUYNEEL, EA ;
DEBRUYNE, GK ;
DEPESTEL, GH ;
DECOSTER, WJ ;
ESPEEL, MF ;
MAREEL, MM .
CLINICAL & EXPERIMENTAL METASTASIS, 1989, 7 (03) :283-300
[17]   Antioxidant and antiradical activities of flavonoids [J].
Burda, S ;
Oleszek, W .
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2001, 49 (06) :2774-2779
[18]   Study of the extraction procedure by experimental design and validation of a LC method for determination of flavonoids in Citrus bergamia juice [J].
Calabrò, ML ;
Galtieri, V ;
Cutroneo, P ;
Tommasini, S ;
Ficarra, P ;
Ficarra, R .
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2004, 35 (02) :349-363
[19]   Effect of hesperetin, a citrus flavonoid, on the liver triacylglycerol content and phosphatidate phosphohydrolase activity in orotic acid-fed rats [J].
Cha, JY ;
Cho, YS ;
Kim, I ;
Anno, T ;
Rahman, SM ;
Yanagita, T .
PLANT FOODS FOR HUMAN NUTRITION, 2001, 56 (04) :349-358
[20]   Pharmacokinetic and pharmacodynamic interaction between grapefruit juice and halofantrine [J].
Charbit, B ;
Becquemont, L ;
Lepère, B ;
Peytavin, G ;
Funck-Brentano, C .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2002, 72 (05) :514-523