Cycloaddition of homochiral imidazolinium ylides: A route to optically active pyrroloimidazoles

被引:48
作者
Jones, RCF
Howard, KJ
Snaith, JS
机构
[1] Department of Chemistry, University of Nottingham, Nottingham NG7 2RD, University Park
[2] Chemistry Department, Open University, Walton Hall
关键词
D O I
10.1016/0040-4039(96)00113-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of either enantiomer of 1-benzyl-4-phenyl-2-imidazoline from phenylglycine is described. 'One-pot' generation and enantioselective 1,3-dipolar cycloaddition of homochiral azomethine ylides prepared from these imidazolines with a range of alkene dipolarophiles affords optically active hexahydropyrroloimidazole adducts.
引用
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页码:1707 / 1710
页数:4
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