MECHANISMS OF DISEASE Graves' Ophthalmopathy

被引：1067

作者：

Bahn, Rebecca S. ^{[1
]}

机构：

[1] Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN 55905 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 362卷 / 08期

关键词：

THYROID-ASSOCIATED OPHTHALMOPATHY; HUMAN ORBITAL FIBROBLASTS; THYROTROPIN RECEPTOR EXPRESSION; FACTOR-I RECEPTOR; T-CELL-ACTIVATION; RHEUMATOID-ARTHRITIS; ADIPOSE-TISSUE; PREADIPOCYTE FIBROBLASTS; CONNECTIVE-TISSUE; GLYCOSAMINOGLYCAN PRODUCTION;

D O I：

10.1056/NEJMra0905750

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article reviews the mechanisms that lead to the development of Graves' ophthalmopathy. A central feature in its development is autoimmunity that involves not only T cells, B cells, and macrophages but also fibroblasts and adipose tissue within the orbit. Intraorbital cytokine-mediated inflammation also has a prominent role. These recent findings suggest new ways of treating this debilitating disease. Copyright © 2010 Massachusetts Medical Society.

引用

页码：726 / 738

页数：13

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