MECHANISMS OF DISEASE Graves' Ophthalmopathy

被引：1067

作者：

Bahn, Rebecca S. ^{[1
]}

机构：

[1] Mayo Clin, Div Endocrinol Diabet Metab & Nutr, Rochester, MN 55905 USA

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 2010年 / 362卷 / 08期

关键词：

THYROID-ASSOCIATED OPHTHALMOPATHY; HUMAN ORBITAL FIBROBLASTS; THYROTROPIN RECEPTOR EXPRESSION; FACTOR-I RECEPTOR; T-CELL-ACTIVATION; RHEUMATOID-ARTHRITIS; ADIPOSE-TISSUE; PREADIPOCYTE FIBROBLASTS; CONNECTIVE-TISSUE; GLYCOSAMINOGLYCAN PRODUCTION;

D O I：

10.1056/NEJMra0905750

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article reviews the mechanisms that lead to the development of Graves' ophthalmopathy. A central feature in its development is autoimmunity that involves not only T cells, B cells, and macrophages but also fibroblasts and adipose tissue within the orbit. Intraorbital cytokine-mediated inflammation also has a prominent role. These recent findings suggest new ways of treating this debilitating disease. Copyright © 2010 Massachusetts Medical Society.

引用

页码：726 / 738

页数：13

共 122 条

[31] Treatment of Graves' disease with rituximab specifically reduces the production of thyroid stimulating autoantibodies [J].

El Fassi, Daniel ;

Banga, J. Paul ;

Gilbert, Jacqueline A. ;

Padoa, Carolyn ;

Hegedus, Laszlo ;

Nielsen, Claus H. .

CLINICAL IMMUNOLOGY, 2009, 130 (03) :252-258

[32] THYROTROPIN RECEPTOR IN NONTHYROID TISSUES [J].

ENDO, T ;

OHNO, M ;

KOTANI, S ;

GUNJI, K ;

ONAYA, T .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 190 (03) :774-779

[33]

ENZMANN DR, 1979, J COMPUT ASSIST TOMO, V3, P815

[34] Pretibial myxedema - Pathophysiology and treatment options [J].

Fatourechi, V .

AMERICAN JOURNAL OF CLINICAL DERMATOLOGY, 2005, 6 (05) :295-309

[35] Development of anti-TNF therapy for rheumatoid arthritis [J].

Feldmann, M .

NATURE REVIEWS IMMUNOLOGY, 2002, 2 (05) :364-371

[36] Design of effective immunotherapy for human autoimmunity [J].

Feldmann, M ;

Steinman, L .

NATURE, 2005, 435 (7042) :612-619

[37] Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy [J].

Feldon, SE ;

Park, DJJ ;

O'Loughlin, CW ;

Nguyen, VT ;

Landskroner-Eiger, S ;

Chang, D ;

Thatcher, TH ;

Phipps, RP .

INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2005, 46 (11) :3913-3921

[38] Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes [J].

Feldon, Steven E. ;

O'Loughlin, Charles W. ;

Ray, Denise M. ;

Landskroner-Eiger, Shira ;

Seweryniak, Kathryn E. ;

Phipps, Richard P. .

AMERICAN JOURNAL OF PATHOLOGY, 2006, 169 (04) :1183-1193

[39] EXPRESSION OF THYROTROPIN-RECEPTOR MESSENGER-RNA IN HEALTHY AND GRAVES-DISEASE RETRO-ORBITAL TISSUE [J].

FELICIELLO, A ;

PORCELLINI, A ;

CIULLO, I ;

BONAVOLONTA, G ;

AVVEDIMENTO, EV ;

FENZI, G .

LANCET, 1993, 342 (8867) :337-338

[40]

FORBES G, 1986, AM J NEURORADIOL, V7, P651

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