Abnormal mitochondrial dynamics and neurodegenerative diseases

被引:216
作者
Su, Bo [1 ]
Wang, Xinglong [1 ]
Zheng, Ling [2 ]
Perry, George [1 ,3 ]
Smith, Mark A. [1 ]
Zhu, Xiongwei [1 ]
机构
[1] Case Western Reserve Univ, Dept Pathol, Cleveland, OH 44106 USA
[2] Wuhan Univ, Coll Life Sci, Wuhan 430072, Peoples R China
[3] Univ Texas San Antonio, Coll Sci, San Antonio, TX 78249 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE | 2010年 / 1802卷 / 01期
关键词
Mitochondrial dynamics; Mitochondrial dysfunction; Mitochondrial distribution; Synaptic dysfunction; DLP1/Drp1; Alzheimer disease; Parkinson disease; AMYOTROPHIC-LATERAL-SCLEROSIS; CYTOCHROME-C-OXIDASE; DEPENDENT PROTEIN-KINASE; NEURONAL CELL-DEATH; ALZHEIMERS-DISEASE; PARKINSONS-DISEASE; HUNTINGTONS-DISEASE; ENERGY-METABOLISM; OXIDATIVE STRESS; PINK1; FUNCTION;
D O I
10.1016/j.bbadis.2009.09.013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mitochondrial dysfunction is a prominent feature of various neurodegenerative diseases. A deeper understanding of the remarkably dynamic nature of mitochondria, characterized by a delicate balance of fission and fusion, has helped to fertilize a recent wave of new studies demonstrating abnormal mitochondrial dynamics in neurodegenerative diseases. This review highlights mitochondrial dysfunction and abnormal mitochondrial dynamics in Alzheimer disease, Parkinson disease, amyotrophic lateral sclerosis, and Huntington disease and discusses how these abnormal mitochondrial dynamics may contribute to mitochondrial and neuronal dysfunction. We propose that abnormal mitochondrial dynamics represents a key common pathway that mediates or amplifies mitochondrial dysfunction and neuronal dysfunction during the course of neurodegeneration. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:135 / 142
页数:8
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