DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development

被引：92

作者：

Durkin, ME

Avner, MR

Huh, CG

Yuan, BZ

Thorgeirsson, SS

Popescu, NC

机构：

[1] NCI, Expt Carcinogenesis Lab, NIH, Bethesda, MD 20892 USA

[2] NCI, SAIC Frederick, Pathol Histotechnol Lab, Vet Pathol Sect, Ft Detrick, MD 21702 USA

来源：

FEBS LETTERS | 2005年 / 579卷 / 05期

关键词：

Rho GTPase-activating protein; knock-out mouse; embryonic lethal;

D O I：

10.1016/j.febslet.2004.12.090

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

DLC-1 (deleted in liver cancer 1) is a Rho GTPase-activating protein that is able to inhibit cell growth and suppress tumorigenesis. We have used homologous recombination to inactivate the mouse DLC-1 gene (Arhgap7). Mice heterozygous for the targeted allele were phenotypically normal, but homozygous mutant embryos did not survive beyond 10.5 days post coitum. Histological analysis revealed that DLC-1(-/-) embryos had defects in the neural tube, brain, heart, and placenta. Cultured fibroblasts from DLC-1-deficient embryos displayed alterations in the organization of actin filaments and focal adhesions. (C) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：1191 / 1196

页数：6

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