Comparison of Alzheimer's disease risk factors in white and African American families

被引：39

作者：

Bachman, DL

Green, RC

Benke, KS

Cupples, LA

Farrer, LA

机构：

[1] Boston Univ, Sch Med, Genet Program, Dept Med, Boston, MA 02118 USA

[2] Med Univ S Carolina, Dept Med, Charleston, SC 29425 USA

[3] Med Univ S Carolina, Dept Psychiat, Charleston, SC 29425 USA

[4] Med Univ S Carolina, Dept Neurol, Charleston, SC 29425 USA

[5] Boston Univ, Sch Med, Dept Neurol, Boston, MA 02118 USA

[6] Boston Univ, Sch Med, Dept Genet & Genom, Boston, MA 02118 USA

[7] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02215 USA

[8] Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02215 USA

来源：

NEUROLOGY | 2003年 / 60卷 / 08期

关键词：

D O I：

10.1212/01.WNL.0000058751.43033.4D

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The associations between alcohol, smoking, and head injury and the risk of AD in 443 African American and 2,336 white participants in the MIRAGE Study were evaluated. Alcohol had a modest protective effect in whites (odds ratio [OR] = 0.82, 95% CI = 0.68 to 0.99), with a similar trend in African Americans (OR = 0.88, 95% CI = 0.54 to 1.4). Head trauma increased the risk of AD in whites (OR = 2.3, 95% CI = 1.8 to 3.0) and African Americans (OR = 2.9, 95% CI = 1.2 to 7.0). Smoking was not associated with AD risk in whites (OR = 0.88, 95% CI = 0.73 to 1.1) or African Americans (OR = 1.0, 95% CI = 0.69 to 1.5). These risks were similar across subsets stratified by the presence or absence of the APOE epsilon4 allele.

引用

页码：1372 / 1374

页数：3

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