Consequences of long-term inflammation - The natural history of asthma

被引:41
作者
Sears, MR [1 ]
机构
[1] McMaster Univ, St Josephs Hosp, Dept Med, Firestone Reg Chest & Allergy Unit, Hamilton, ON L8N 4A6, Canada
关键词
D O I
10.1016/S0272-5231(05)70269-0
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
Childhood asthma often improves or remits, especially if mild; however, impaired lung function, increased airway responsiveness, a greater degree of atopy, and concurrent atopic disease all predispose to a poorer prognosis and persistence into adulthood. Exposure to environmental and personal tobacco smoke also contribute to a worse prognosis. Adults with asthma rarely experience full remission, but show increased rates of decline of lung function. The severity and duration of asthma, together with delay in initiating appropriate treatment, all contribute to adverse outcomes, with airway remodeling contributing to increasing and sometimes irreversible airflow obstruction
引用
收藏
页码:315 / +
页数:16
相关论文
共 75 条
  • [71] DOES THE CONTINUOUS USE OF BRONCHODILATORS MASK THE PROGRESSION OF ASTHMA OR CHRONIC-BRONCHITIS
    VANSCHAYCK, CP
    FOLGERING, H
    DENOTTER, JJ
    TIRIMANNA, P
    VANWEEL, C
    [J]. FAMILY PRACTICE, 1992, 9 (04) : 397 - 404
  • [72] Addition of salmeterol versus doubling the dose of beclomethasone in children with asthma
    Verberne, AAPH
    Frost, C
    Duiverman, EJ
    Grol, MH
    Kerrebijn, KF
    Raaymakers, JAM
    Pocock, SJ
    Bogaard, JM
    van Nierop, JC
    Nagelkerke, AF
    Thio, B
    Schouten, TJ
    van Essen-Zandvliet, EEM
    Denteneer, A
    Gerritsen, J
    Grol, MJ
    Roorda, RJ
    Hendriks, JJE
    Duiverman, EJ
    Kouwenberg, JM
    van der Laag, J
    Brackel, HJL
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1998, 158 (01) : 213 - 219
  • [73] Bronchial hyperresponsiveness, atopy, airway inflammation, and asthma
    Warner, JO
    [J]. PEDIATRIC ALLERGY AND IMMUNOLOGY, 1998, 9 (02) : 56 - 60
  • [74] EFFECTS OF ASTHMA ON PULMONARY-FUNCTION IN CHILDREN - A LONGITUDINAL POPULATION-BASED STUDY
    WEISS, ST
    TOSTESON, TD
    SEGAL, MR
    TAGER, IB
    REDLINE, S
    SPEIZER, FE
    [J]. AMERICAN REVIEW OF RESPIRATORY DISEASE, 1992, 145 (01): : 58 - 64
  • [75] PREVALENCE, NATURAL HISTORY, AND RELATIONSHIP OF WHEEZY BRONCHITIS AND ASTHMA IN CHILDREN - AN EPIDEMIOLOGICAL STUDY
    WILLIAMS, H
    MCNICOL, KN
    [J]. BRITISH MEDICAL JOURNAL, 1969, 4 (5679) : 321 - &