Rotating magnetic macrospheres as heating mechanism for remote controlled drug release

被引：13

作者：

Steinke, Franziska

Andrae, Wilfried

Heide, Rainer

Werner, Christoph

Bellemann, Matthias Erich

机构：

[1] Univ Appl Sci, Dept Biomed Engn, Jena, Germany

[2] Inst Phys HochTechnol EV, Jena, Germany

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2007年 / 311卷 / 01期

关键词：

friction losses; rotating magnetic field; special torque-meter; thermal resistance; viscosity;

D O I：

10.1016/j.jmmm.2006.10.1193

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A permanent magnetic macrosphere (diameter: 5 mm) spherically seated in an oil bearing inside an experimental capsule (comparable to a hard gelatine capsule size 2) is turned by a rotating magnetic field (H <= 5 kA/m; frequency v <= 500 Hz) and causes a temperature rise up to about 60 degrees C. In order to find further possible improvements, the experimental results were compared to theoretical expectations. First experiments using improved thermal isolation yielded temperatures of about 100 degrees C. The heating can be used as a mechanism to remotely release drugs in the gastrointestinal tract. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：216 / 218

页数：3

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