Saccadic eye movements in schizophrenic patients

被引:78
作者
Karoumi, B
Ventre-Dominey, J
Vighetto, A
Dalery, J
d'Amato, T
机构
[1] Univ Lyon 1, Hop Vinatier, Inst Psychopathol Cognit & Neurobiol, Jeune Equipe 1882, F-69677 Lyon Bron, France
[2] INSERM, Unite 94 Vis & Motricite, F-69500 Lyon Bron, France
[3] Hop Neurol, Serv Neuroophtalmol, F-69003 Lyon, France
关键词
antisaccades; remembered saccades; oculomotor control; prefrontal cortex;
D O I
10.1016/S0165-1781(97)00126-1
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
The nature of saccadic abnormalities in schizophrenia was investigated in three different paradigms: (1) the visually guided saccade; (2) the antisaccade; and (3) the remembered saccade paradigm. Subjects comprised 14 schizophrenic patients and 14 normal volunteers. Deficits in the schizophrenic group were observed in the antisaccade and remembered saccade tasks, both of which were characterized by increased latency and reduced gain. Moreover, in the antisaccade task, schizophrenic patients showed an increased number of errors compared with control subjects. Saccadic abnormalities in the patients were correlated with impaired performance on the Wisconsin Card Sorting Test. These data suggest that schizophrenic patients have difficulty in inhibiting reflexive saccades and in producing voluntary saccades. The implications of these findings for a prefrontal cortex dysfunction involved in oculomotor control in schizophrenia are discussed. (C) 1998 Elsevier Science Ireland Ltd.
引用
收藏
页码:9 / 19
页数:11
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