Structural biology - A mechanism for all polymerases

被引：483

作者：

Steitz, TA

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

[2] Yale Univ, Howard Hughes Med Inst, New Haven, CT 06520 USA

来源：

NATURE | 1998年 / 391卷 / 6664期

关键词：

D O I：

10.1038/34542

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Replication of the genome is one of the most fundamental of biological activities, hence the interest in the mechanism by which the enzymes concerned -- the polynucleotide polymerases -- carry out the process. The co-crystal structures of the DNA polymerase that replicates bacteriophage T7, and of theBacillus stearothermophilusDNA polymerase large fragment, provide significant insights into the catalytic mechanism, fidelity and processivity of DNA polymerases.

引用

页码：231 / 232

页数：2

共 12 条

[1] BRAUTIGAM C, IN PRESS CURR OPIN S
[2] Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution
Doublié, S
Tabor, S
Long, AM
Richardson, CC
Ellenberger, T
[J]. NATURE, 1998, 391 (6664) : 251 - 258
[3] Structure of Taq polymerase with DNA at the polymerase active site
Eom, SH
Wang, JM
Steitz, TA
[J]. NATURE, 1996, 382 (6588) : 278 - 281
[4] Structure of the RNA-dependent RNA polymerase of poliovirus
Hansen, JL
Long, AM
Schultz, SC
[J]. STRUCTURE, 1997, 5 (08) : 1109 - 1122
[5] CRYSTAL-STRUCTURE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 REVERSE-TRANSCRIPTASE COMPLEXED WITH DOUBLE-STRANDED DNA AT 3.0 ANGSTROM RESOLUTION SHOWS BENT DNA
JACOBOMOLINA, A
DING, JP
NANNI, RG
CLARK, AD
LU, XD
TANTILLO, C
WILLIAMS, RL
KAMER, G
FERRIS, AL
CLARK, P
HIZI, A
HUGHES, SH
ARNOLD, E
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) : 6320 - 6324
[6] Visualizing DNA replication in a catalytically active Bacillus DNA polymerase crystal
Kiefer, JR
Mao, C
Braman, JC
Beese, LS
[J]. NATURE, 1998, 391 (6664) : 304 - 307
[7] KOHLSTAEDT LA, 1992, SCIENCE, V256, P1873
[8] STRUCTURES OF TERNARY COMPLEXES OF RAT DNA-POLYMERASE-BETA, A DNA TEMPLATE-PRIMER, AND DDCTP
PELLETIER, H
SAWAYA, MR
KUMAR, A
WILSON, SH
KRAUT, J
[J]. SCIENCE, 1994, 264 (5167) : 1891 - 1903
[9] CRYSTAL-STRUCTURE OF BACTERIOPHAGE-T7 RNA-POLYMERASE AT 3.3-ANGSTROM RESOLUTION
SOUSA, R
CHUNG, YJ
ROSE, JP
WANG, BC
[J]. NATURE, 1993, 364 (6438) : 593 - 599
[10] DNA-DEPENDENT AND RNA-DEPENDENT DNA-POLYMERASES
STEITZ, TA
[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY, 1993, 3 (01) : 31 - 38

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