Analysis of resveratrol as a lung cancer chemopreventive agent in A/J mice exposed to benzo[α] pyrene

被引：47

作者：

Berge, G ^{[1
]}

Ovrebo, S ^{[1
]}

Eilertsen, E ^{[1
]}

Haugen, A ^{[1
]}

Mollerup, S ^{[1
]}

机构：

[1] Natl Inst Occupat Hlth, Dept Toxicol, N-0033 Oslo, Norway

来源：

BRITISH JOURNAL OF CANCER | 2004年 / 91卷 / 07期

关键词：

lung carcinogenesis; benzo[alpha] pyrene; resveratrol; adducts; CYP1A1; CYP1B1;

D O I：

10.1038/sj.bjc.6602125

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Resveratrol inhibits PAH bioactivation through reduced expression of the CYP1A1 and CYP1B1 genes in human bronchial epithelial cells. Ad libitum access to a diet containing resveratrol showed no effect on benzo[ a] pyrene-induced lung tumorigenesis in A/J mice. Also, resveratrol did not change CYP1A1 and CYP1B1 gene expression or benzo[ a] pyrene protein adduct levels in the lung tissue. The lack of chemopreventive activity may have been caused by insufficient concentrations or nonreactive forms of resveratrol in the lungs.

引用

页码：1380 / 1383

页数：4

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