Distinct functions of DC-SIGN and its homologues L-SIGN (DC-SIGNR) and mSIGNR1 in pathogen recognition and immune regulation

被引：96

作者：

Koppel, EA ^{[1
]}

van Gisbergen, KPJM ^{[1
]}

Geijtenbeek, TBH ^{[1
]}

van Kooyk, Y ^{[1
]}

机构：

[1] Vrije Univ Amsterdam Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands

来源：

CELLULAR MICROBIOLOGY | 2005年 / 7卷 / 02期

关键词：

D O I：

10.1111/J.1462-5822.2004.00480.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Antigen presenting cells express C-type lectins that are involved in pathogen capture, processing and antigen presentation to induce immune responses against these pathogens. However, it is becoming clear that pathogens have evolved to subvert the function of some C-type lectins to escape immune surveillance. An important C-type lectin family is represented by DC-SIGN and its homologues in human and mouse. Here we discuss the structure in relation to the pathogen binding specificity of the SIGN receptors and the function of these receptors in mouse and humans.

引用

页码：157 / 165

页数：9

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