Synthesis of functionalized heterocycles via a tandem Staudinger/aza-Wittig/Ugi multicomponent reaction

被引：61

作者：

Timmer, MSM ^{[1
]}

Risseeuw, MDP ^{[1
]}

Verdoes, M ^{[1
]}

Filippov, DV ^{[1
]}

Plaisier, JR ^{[1
]}

van der Marel, GA ^{[1
]}

Overkleeft, HS ^{[1
]}

van Boom, JH ^{[1
]}

机构：

[1] Leiden Univ, Leiden Inst Chem, Gorlaeus Labs, NL-2300 RA Leiden, Netherlands

来源：

TETRAHEDRON-ASYMMETRY | 2005年 / 16卷 / 01期

关键词：

D O I：

10.1016/j.tetasy.2004.11.079

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

By combining a Staudinger/aza-Wittig and an Ugi three-cornponent reaction in a one-pot process (SAWU-3CR), a new and efficient multicomponent reaction was developed. The application of this reaction on readily available azido-aldehydes gave easy access to highly functionalized, enantiomerically pure pipecolic acid amides and bridged morpholine amide derivatives. The versatility of this methodology is demonstrated by the construction of a molecular library. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：177 / 185

页数：9

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