Ascorbate-stimulated lipid peroxidation and non-heme iron concentrations in Alzheimer disease

被引：10

作者：

Andorn, AC ^{[1
]}

Britton, RS

Bacon, BR

Kalaria, RR

机构：

[1] St Louis Univ, Sch Med, Dept Psychiat, St Louis, MO 63014 USA

[2] St Louis Univ, Sch Med, Dept Internal Med, Div Gastroenterol & Hepatol, St Louis, MO 63014 USA

[3] Vet Adm Med Ctr, Psychiat Serv, St Louis, MO 63125 USA

[4] Case Western Reserve Univ, Sch Med, Dept Neurol, Cleveland, OH 44106 USA

来源：

MOLECULAR AND CHEMICAL NEUROPATHOLOGY | 1998年 / 33卷 / 01期

关键词：

Alzheimer disease; lipid peroxidation; iron; brain; antioxidants; aging;

D O I：

10.1007/BF02815856

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Lipid peroxidation has been suggested to be a potential cause of neuronal damage in neurodegenerative diseases. Changes in several parameters of lipid peroxidation, including basal (unstimulated) lipid peroxidation, stimulated lipid peroxidation, tissue iron concentrations, and the concentrations of some oxygen radical scavengers, have been reported in neurodegenerative diseases. However, the in vitro interaction of oxygen radical scavengers and stimulated lipid peroxidation in neurodegenerative disease has been less well-studied. The purpose of the present study was to determine the effects of oxygen radical scavengers on ascorbate-stimulated Lipid peroxidation in Alzheimer disease (AD). We have found that some parameters of ascorbate-stimulated lipid peroxidation are altered in AD and that the effects of superoxide dismutase (SOD) on ascorbate-stimulated lipid peroxidation are significantly different in AD as compared to aged.

引用

页码：15 / 26

页数：12