In vitro simultaneous measurement of refractive index and thickness of biological tissue by the low coherence interferometry

被引：71

作者：

Ohmi, M ^{[1
]}

Ohnishi, Y ^{[1
]}

Yoden, K ^{[1
]}

Haruna, M ^{[1
]}

机构：

[1] Osaka Univ, Fac Med, Sch Allied Hlth Sci, Suita, Osaka 5650871, Japan

来源：

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING | 2000年 / 47卷 / 09期

关键词：

in vitro measurement; low coherence interferometry; opto-mechatronics; simultaneous measurement of refractive index and thickness;

D O I：

10.1109/10.867961

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

We proposed and demonstrated in vitro simultaneous measurement of refractive index and thickness of biological tissue. The technique is based on the low coherence interferometry combined with precise translation stages. Refractive indices were determined with the accuracy of less than 1% for tissue samples of a few hundred micron thickness, including chicken tissue, human tooth and nail. Simultaneous measurement of refractive index and thickness of multilayer tissue are also demonstrated.

引用

页码：1266 / 1270

页数：5

共 17 条

[1] REFRACTIVE-INDEX OF SOME MAMMALIAN-TISSUES USING A FIBER OPTIC CLADDING METHOD [J].

BOLIN, FP ;

PREUSS, LE ;

TAYLOR, RC ;

FERENCE, RJ .

APPLIED OPTICS, 1989, 28 (12) :2297-2303

[2] A REVIEW OF THE OPTICAL-PROPERTIES OF BIOLOGICAL TISSUES [J].

CHEONG, WF ;

PRAHL, SA ;

WELCH, AJ .

IEEE JOURNAL OF QUANTUM ELECTRONICS, 1990, 26 (12) :2166-2185

[3] MEASUREMENT OF THE THICKNESS OF FUNDUS LAYERS BY PARTIAL COHERENCE TOMOGRAPHY [J].

DREXLER, W ;

HITZENBERGER, CK ;

SATTMANN, H ;

FERCHER, AF .

OPTICAL ENGINEERING, 1995, 34 (03) :701-710

[4] EYE-LENGTH MEASUREMENT BY INTERFEROMETRY WITH PARTIALLY COHERENT-LIGHT [J].

FERCHER, AF ;

MENGEDOHT, K ;

WERNER, W .

OPTICS LETTERS, 1988, 13 (03) :186-188

[5] Simultaneous measurement of thicknesses and refractive indices of multiple layers by a low-coherence confocal interference microscope [J].

Fukano, T ;

Yamaguchi, I .

OPTICS LETTERS, 1996, 21 (23) :1942-1944

[6] Simultaneous measurement of the phase and group indices and the thickness of transparent plates by low-coherence interferometry [J].

Haruna, M ;

Ohmi, M ;

Mitsuyama, T ;

Tajiri, H ;

Maruyama, H ;

Hashimoto, M .

OPTICS LETTERS, 1998, 23 (12) :966-968

[7] MEASUREMENT OF CORNEAL THICKNESS BY LOW-COHERENCE INTERFEROMETRY [J].

HITZENBERGER, CK .

APPLIED OPTICS, 1992, 31 (31) :6637-6642

[8] OPTICAL COHERENCE TOMOGRAPHY [J].

HUANG, D ;

SWANSON, EA ;

LIN, CP ;

SCHUMAN, JS ;

STINSON, WG ;

CHANG, W ;

HEE, MR ;

FLOTTE, T ;

GREGORY, K ;

PULIAFITO, CA ;

FUJIMOTO, JG .

SCIENCE, 1991, 254 (5035) :1178-1181

[9]

INOUE S, 1999, P 13 INT C OPT FIB S, P124

[10] Measurement method of the refractive index of biotissue by total internal reflection [J].

Li, H ;

Xie, SS .

APPLIED OPTICS, 1996, 35 (10) :1793-1795

← 1 2 →