A role for BDNF in cocaine reward and relapse

被引：27

作者：

Schoenbaum, Geoffrey

Stalnaker, Thomas A.

Shaham, Yavin

机构：

[1] Univ Maryland Baltimore Cty, Dept Psychol, Baltimore, MD 21228 USA

[2] Natl Inst Drug Abuse, Intramural Res Program, Behav Neurosci Branch, US Dept HHS,NIH, Baltimore, MD 21224 USA

来源：

NATURE NEUROSCIENCE | 2007年 / 10卷 / 08期

关键词：

D O I：

10.1038/nn0807-935

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Brain-derived neurotrophic factor (BDNF) is important in regulating synaptic plasticity in the brain areas that process reward information. A new study reports that BDNF in the nucleus accumbens, a brain area critical for the rewarding effects of cocaine, promotes persistent cocaine-seeking behaviors and heightens relapse vulnerability.

引用

页码：935 / 936

页数：2

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