A new entry to hydroxylated pyrrolizidines

被引：32

作者：

Gallos, JK ^{[1
]}

Sarli, VC ^{[1
]}

Koftis, TV ^{[1
]}

Coutouli-Argyropoulou, E ^{[1
]}

机构：

[1] Aristotelian Univ Salonika, Dept Chem, GR-54006 Salonika, Greece

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 24期

关键词：

glycosidase inhibitors; D-ribose; hetero-Diels-Alder reaction; pyrrolizidine alkaloids; hydrogenation;

D O I：

10.1016/S0040-4039(00)00732-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A short and efficient synthesis of(1R,2S,5R,8S)-5-hydroxymethyl- 1,2-dihydroxypyrrolizidine 1, by hetero-Diels-Alder addition of a nitrosoalkene to a pent-4-enofuranoside derived from D-ribose, followed by reductive opening of the oxazine ring formed, is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：4819 / 4822

页数：4

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