Inhibitory effects of fatty acid monoesters of 2-O-β-D-glucosylglycerol on Epstein-Barr virus activation

被引：25

作者：

Colombo, D

Scala, A

Taino, IM

Toma, L

Ronchetti, F

Tokuda, H

Nishino, H

Nagatsu, A

Sakakibara, J

机构：

[1] Univ Milan, Dipartimento Chim & Biochim Med, I-20133 Milan, Italy

[2] Univ Pavia, Dipartimento Chim Organ, I-27100 Pavia, Italy

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 602, Japan

[4] Nagoya City Univ, Fac Pharmaceut Sci, Mizuho Ku, Nagoya, Aichi 467, Japan

来源：

CANCER LETTERS | 1998年 / 123卷 / 01期

关键词：

glycosylglycerols; cancer chemoprevention; anti-tumor promoters; Epstein-Barr virus early antigen;

D O I：

10.1016/S0304-3835(97)00410-2

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In a screening for cancer chemopreventing agents several glycosylglycerols were found to be active. In order to optimize the anti-tumor activity of this class of compounds, a series of 1-O-acyl-2-O-beta-D-glucopyranosyl-sn-glycerols differing in the acyl chain length, which varied from C-4 to C-18, were examined for their in vitro anti-tumor promoting effects on Epstein-Barr virus early antigen (EBV-BA) activation induced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA). Among the compounds tested, the monohexanoyl derivative was the most active and, noteworthy, the most potent compound of the glycosylglycerol series hitherto known. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：83 / 86

页数：4

共 10 条

[1]

COLOMBO D, 1995, TETRAHEDRON LETT, V36, P4865

[2] 1-O-, 2-O- and 3-O-beta-glycosyl-sn-glycerols: Structure-anti-tumor-promoting activity relationship [J].