Overcoming apoptosis: new methods for improving protein-expression systems

被引：67

作者：

Mastrangelo, AJ ^{[1
]}

Betenbaugh, MJ ^{[1
]}

机构：

[1] Johns Hopkins Univ, Dept Chem Engn, Baltimore, MD 21218 USA

来源：

TRENDS IN BIOTECHNOLOGY | 1998年 / 16卷 / 02期

关键词：

D O I：

10.1016/S0167-7799(97)01159-1

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cellular suicide, or apoptosis, is responsible for a significant proportion of cell death in many bioprocesses, With the progressive elucidation of the biochemical and genetic events leading to this form of cell death, it is now possible to implement strategies for extending the productive lifetimes of cells in culture, These strategies may include nutritional, genetic and chemical methods that enhance cell survival and performance during the critical stages of a culture process, leading to improvements in the production capacity for valuable biotechnological products.

引用

页码：88 / 95

页数：8

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