Allergic and autoimmune reactions to xenobiotics:: how do they arise?

被引：182

作者：

Griem, P ^{[1
]}

Wulferink, M ^{[1
]}

Sachs, B ^{[1
]}

González, JB ^{[1
]}

Gleichmann, E ^{[1
]}

机构：

[1] Univ Dusseldorf, Med Inst Environm Hyg, Div Immunol, D-40225 Dusseldorf, Germany

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 03期

关键词：

D O I：

10.1016/S0167-5699(97)01219-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Induction of allergic and autoimmune reactions by drugs and other chemicals constitutes a major public health problem. Elucidation of the underlying mechanisms might help improve diagnostic tools and therapeutic approaches. Here, Peter Griem and colleagues focus on several aspects of neoantigen formation by xenobiotics: metabolism of xenobiotics into reactive, haptenic metabolites; polymorphisms of metabolizing enzymes; induction of costimulatory signals; and sensitization of T cells.

引用

页码：133 / 141

页数：9

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