The effects of steroid hormones in HIV-related neurotoxicity: A mini review

被引：11

作者：

Brooke, SM ^{[1
]}

Sapolsky, RM ^{[1
]}

机构：

[1] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

来源：

BIOLOGICAL PSYCHIATRY | 2000年 / 48卷 / 09期

关键词：

gp120; HIV; glucocorticoids; estrogen; AIDS-related dementia (ADC); review;

D O I：

10.1016/S0006-3223(00)00922-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This review examines the interaction of steroid hormones, glucocorticoids and estrogen, and gp120, a possible causal agent of acquired immune deficiency syndrome-related dementia complex. The first part of the review examines the data and mechanisms by which gp120 may cause neurotoxicity and by which these steroid hormones effect cell death in general. The second part of the review summarizes recent experiments that show how these steroid hormones can modulate the toxic effects of gp120 and glucocorticoids exacerbating toxicity, and estrogen decreasing it. We then examine the limited in vivo and clinical data relating acquired immune deficiency syndrome-related dementia complex and steroid hormones and speculate on the possible clinical significance of these findings with respect to acquired immune deficiency syndrome-related dementia complex. (C) 2000 Society of Biological Psychiatry.

引用

收藏

页码：881 / 893

页数：13

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