The effect of inflammation on mucociliary clearance in asthma - An overview

被引:60
作者
Del Donno, M
Bittesnich, D
Chetta, A
Olivieri, D
Lopez-Vidriero, MT
机构
[1] Univ Parma, Ist Clin Malattie Apparato Resp, I-43100 Parma, Italy
[2] Boehringer Ingelheim Ltd, Bracknell, Berks, England
关键词
asthma; inflammation; mucociliary clearance;
D O I
10.1378/chest.118.4.1142
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Mucociliary clearance (MCC) is one of the most important nonspecific defense mechanisms of the respiratory tract, and its impairment is a well-documented feature of chronic respiratory diseases, including asthma. In vitro and in vivo data suggest that several inflammatory mediators influence the mucociliary apparatus. Epithelial damage and functional abnormalities have been described in bronchial asthma, along with changes in mucus-secreting cells and the chemical and rheological properties of airway fluid. Although the mechanisms of MCC impairment in asthma are not clearly understood, data in the recent literature suggest that airway inflammation plays a major role. In this article, we review studies on MCC alterations in light of up-to-date findings on pathogenetic mechanisms in asthma.
引用
收藏
页码:1142 / 1149
页数:8
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