Fetal origins of adult disease: epidemiology and mechanisms

被引:67
作者
Byrne, CD
Phillips, DI
机构
[1] Univ Southampton, Southampton Gen Hosp, Sch Med, Endocrine & Metab Unit, Southampton SO16 6YD, Hants, England
[2] Univ Southampton, Southampton Gen Hosp, MRC, Environm Epidemiol Unit, Southampton SO16 6YD, Hants, England
关键词
atherosclerotic vascular disease; type; 2; diabetes; birth weight;
D O I
10.1136/jcp.53.11.822
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
The past 10 years have provided unequivocal evidence that there are associations between birth size measures and future development of adult diseases, such as type 2 diabetes and coronary artery disease. Despite initial concern that bias or residual confounding in the analyses had produced these rather bizarre associations, the findings have now been reproduced in different cohorts by independent investigators from many parts of the world. The challenge for the next decade must be to discover the cellular and molecular mechanisms giving rise to these associations. If this aim is accomplished, it might be possible to devise strategies to reduce the impact of these disabling, chronic, and expensive diseases. The purpose of this review is to describe some of the relevant, important, sand more recent epidemiological studies, and also to discuss potential mechanisms underpinning the associations.
引用
收藏
页码:822 / 828
页数:7
相关论文
共 52 条
  • [21] Intrauterine programming of hypertension by glucocorticoids
    LangleyEvans, SC
    [J]. LIFE SCIENCES, 1997, 60 (15) : 1213 - 1221
  • [22] Law CM, 1996, J HYPERTENS, V14, P935
  • [23] THINNESS AT BIRTH AND GLUCOSE-TOLERANCE IN 7-YEAR-OLD CHILDREN
    LAW, CM
    GORDON, GS
    SHIELL, AW
    BARKER, DJP
    HALES, CN
    [J]. DIABETIC MEDICINE, 1995, 12 (01) : 24 - 29
  • [24] LEE S, 1990, Molecular and Cellular Neuroscience, V1, P168
  • [25] Leon DA, 1996, BRIT MED J, V312, P401, DOI 10.1136/bmj.312.7028.401
  • [26] Dexamethasone in the last week of pregnancy attenuates hippocampal glucocorticoid receptor gene expression and elevates blood pressure in the adult offspring in the rat
    Levitt, NS
    Lindsay, RS
    Holmes, MC
    Seckl, JR
    [J]. NEUROENDOCRINOLOGY, 1996, 64 (06) : 412 - 418
  • [27] Inhibition of 11 beta-hydroxysteroid dehydrogenase in pregnant rats and the programming of blood pressure in the offspring
    Lindsay, RS
    Lindsay, RM
    Edwards, CRW
    Seckl, JR
    [J]. HYPERTENSION, 1996, 27 (06) : 1200 - 1204
  • [28] Mothers' pelvic size, fetal growth, and death from stroke and coronary heart disease in men in the UK
    Martyn, CN
    Barker, DJP
    Osmond, C
    [J]. LANCET, 1996, 348 (9037) : 1264 - 1268
  • [29] BIRTH-WEIGHT AND NON-INSULIN-DEPENDENT DIABETES - THRIFTY GENOTYPE, THRIFTY PHENOTYPE, OR SURVIVING SMALL BABY GENOTYPE
    MCCANCE, DR
    PETTITT, DJ
    HANSON, RL
    JACOBSSON, LTH
    KNOWLER, WC
    BENNETT, PH
    [J]. BRITISH MEDICAL JOURNAL, 1994, 308 (6934) : 942 - 945
  • [30] Glucose tolerance and resistance to insulin-stimulated glucose uptake in men aged 70 years in relation to size at birth
    McKeigue, PM
    Lithell, HO
    Leon, DA
    [J]. DIABETOLOGIA, 1998, 41 (10) : 1133 - 1138