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Rescue of Hantaan virus minigenomes

被引：72
作者：
Flick, K
Hooper, JW
Schmaljohn, CS
Pettersson, RF
Feldmann, H
Flick, R
机构：
[1] Hlth Canada, Canadian Sci Ctr Human & Anim Hlth, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB R3E 3R2, Canada
[2] USA, Med Res Inst Infect Dis, Dept Mol Virol, Div Virol, Frederick, MD 21702 USA
[3] Karolinska Inst, Stockholm Branch, Ludwig Inst Canc Res, SE-17177 Stockholm, Sweden
[4] Univ Manitoba, Dept Med Microbiol, Winnipeg, MB R3E 0W3, Canada
来源：
VIROLOGY | 2003年 / 306卷 / 02期
基金：
加拿大自然科学与工程研究理事会; 加拿大健康研究院;
关键词：
D O I：
10.1016/S0042-6822(02)00070-3
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Hantavirus infections are a major public health concern worldwide. Their widespread geographical distribution and their ability to produce serious, often fatal, human disease underline the need for a system that allows manipulation of these viruses. We describe here the first successful establishment of a reverse genetics technology for Hantaan virus, the prototype of the genus Hantavirus. The system offers a unique opportunity to study the biology of hantaviruses, the pathogenesis of the diseases, and the efficacy of antiviral and prophylactic measures against hantavirus infections. (C) 2003 Elsevier Science (USA). All rights reserved.
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页码：219 / 224
页数：6
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