Cryptotomography: Reconstructing 3D Fourier Intensities from Randomly Oriented Single-Shot Diffraction Patterns

被引：83

作者：

Loh, N. D. ^{[1
]}

Bogan, M. J. ^{[2
]}

Elser, V. ^{[1
]}

Barty, A.

Boutet, S. ^{[2
]}

Bajt, S.

Hajdu, J. ^{[4
]}

Ekeberg, T. ^{[4
]}

Maia, F. R. N. C. ^{[4
]}

Schulz, J.

Seibert, M. M. ^{[4
]}

Iwan, B. ^{[4
]}

Timneanu, N. ^{[4
]}

Marchesini, S. ^{[5
]}

Schlichting, I. ^{[3
,6
]}

Shoeman, R. L. ^{[3
,6
]}

Lomb, L. ^{[3
,6
]}

Frank, M. ^{[7
]}

Liang, M.

Chapman, H. N. ^{[8
]}

机构：

[1] Cornell Univ, Atom & Solid State Phys Lab, Ithaca, NY 14853 USA

[2] SLAC Natl Accelerator Lab, Menlo Pk, CA 94025 USA

[3] DESY, Ctr Free Electron Laser Sci, Max Planck Adv Study Grp, D-22607 Hamburg, Germany

[4] Uppsala Univ, Dept Cell & Mol Biol, Lab Mol Biophys, SE-75124 Uppsala, Sweden

[5] Univ Calif Berkeley, Lawrence Berkeley Lab, Berkeley, CA 94720 USA

[6] Max Planck Inst Med Res, D-69120 Heidelberg, Germany

[7] Lawrence Livermore Natl Lab, Livermore, CA 94550 USA

[8] Univ Hamburg, D-22761 Hamburg, Germany

来源：

PHYSICAL REVIEW LETTERS | 2010年 / 104卷 / 22期

基金：

瑞典研究理事会;

关键词：

FREE-ELECTRON LASER;

D O I：

10.1103/PhysRevLett.104.225501

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We reconstructed the 3D Fourier intensity distribution of monodisperse prolate nanoparticles using single-shot 2D coherent diffraction patterns collected at DESY's FLASH facility when a bright, coherent, ultrafast x-ray pulse intercepted individual particles of random, unmeasured orientations. This first experimental demonstration of cryptotomography extended the expansion-maximization-compression framework to accommodate unmeasured fluctuations in photon fluence and loss of data due to saturation or background scatter. This work is an important step towards realizing single-shot diffraction imaging of single biomolecules.

引用

页数：5

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