Tumor necrosis factors: Pivotal components of pregnancy?

被引:150
作者
Hunt, JS
Chen, HL
Miller, L
机构
[1] UNIV KANSAS, MED CTR, DEPT PATHOL & LAB MED, KANSAS CITY, KS 66160 USA
[2] UNIV KANSAS, MED CTR, DEPT PHYSIOL, KANSAS CITY, KS 66160 USA
关键词
D O I
10.1095/biolreprod54.3.554
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Tumor necrosis factor alpha is a major component of the infection-stimulated cytokine milieux associated with preterm labor and pregnancy termination. As a consequence, this potent factor is thought by some to have exclusively negative effects on the course of pregnancy. Yet in humans and other mammals, messenger RNA hybridizing with tumor necrosis factor alpha cRNA probes and protein detected by anti-tumor necrosis factor alpha have been identified in normal cycling and pregnant uteri, placentas, and embryos, consistent with an important role for tumor necrosis factor in female reproduction and embryonic development. Here, evidence for this intriguing dichotomy is presented, unresolved aspects are discussed, and potential roles for uteroplacental and embryonic tumor necrosis factor are proposed.
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页码:554 / 562
页数:9
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共 79 条
[51]  
PEPPEL K, 1993, J IMMUNOL, V151, P5699
[52]   MICE DEFICIENT FOR THE 55KD TUMOR-NECROSIS-FACTOR RECEPTOR ARE RESISTANT TO ENDOTOXIC-SHOCK, YET SUCCUMB TO L-MONOCYTOGENES INFECTION [J].
PFEFFER, K ;
MATSUYAMA, T ;
KUNDIG, TM ;
WAKEHAM, A ;
KISHIHARA, K ;
SHAHINIAN, A ;
WIEGMANN, K ;
OHASHI, PS ;
KRONKE, M ;
MAK, TW .
CELL, 1993, 73 (03) :457-467
[53]  
PHILIPPEAUX MM, 1993, AM J PATHOL, V143, P480
[54]   CLONING AND EXPRESSION ANALYSIS OF THE MURINE LYMPHOTOXIN BETA-GENE [J].
POKHOLOK, DK ;
MAROULAKOU, IG ;
KUPRASH, DV ;
ALIMZHANOV, MB ;
KOZLOV, SV ;
NOVOBRANTSEVA, TI ;
TURETSKAYA, RL ;
GREEN, JE ;
NEDOSPASOV, SA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (03) :674-678
[55]   EXPRESSION AND LOCALIZATION OF MESSENGER-RNA FOR TUMOR-NECROSIS-FACTOR RECEPTOR (TNF-R)-I AND TNF-RII IN PREGNANT MOUSE UTERUS AND PLACENTA [J].
ROBY, KF ;
LAHAM, N ;
KRONING, H ;
TERRANOVA, PF ;
HUNT, JS .
ENDOCRINE, 1995, 3 (08) :557-562
[56]   MOUSE ENDOMETRIAL TUMOR-NECROSIS-FACTOR-ALPHA MESSENGER-RIBONUCLEIC-ACID AND PROTEIN - LOCALIZATION AND REGULATION BY ESTRADIOL AND PROGESTERONE [J].
ROBY, KF ;
HUNT, JS .
ENDOCRINOLOGY, 1994, 135 (06) :2780-2789
[57]   DIFFERENTIAL RESPONSES OF PHENOTYPICALLY DISTINCT RAT TROPHOBLAST CELL-LINES TO MHC CLASS-I ANTIGEN-INDUCING CYTOKINES [J].
ROBY, KF ;
HAMLIN, GP ;
SOARES, MJ ;
HUNT, JS .
PLACENTA, 1994, 15 (06) :577-590
[58]   INFECTION AND LABOR .4. CACHECTIN TUMOR NECROSIS FACTOR IN THE AMNIOTIC-FLUID OF WOMEN WITH INTRAAMNIOTIC INFECTION AND PRETERM LABOR [J].
ROMERO, R ;
MANOGUE, KR ;
MITCHELL, MD ;
WU, YK ;
OYARZUN, E ;
HOBBINS, JC ;
CERAMI, A .
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 1989, 161 (02) :336-341
[59]   MICE LACKING THE TUMOR-NECROSIS-FACTOR RECEPTOR-1 ARE RESISTANT TO TNF-MEDIATED TOXICITY BUT HIGHLY SUSCEPTIBLE TO INFECTION BY LISTERIA-MONOCYTOGENES [J].
ROTHE, J ;
LESSLAUER, W ;
LOTSCHER, H ;
LANG, Y ;
KOEBEL, P ;
KONTGEN, F ;
ALTHAGE, A ;
ZINKERNAGEL, R ;
STEINMETZ, M ;
BLUETHMANN, H .
NATURE, 1993, 364 (6440) :798-802
[60]  
SHANKER G, 1994, LYMPHOKINE CYTOK RES, V13, P377