Apoptosis induced by the lymphocyte effector molecule perforin

被引：119

作者：

Bolitho, Paul

Voskoboinik, Ilia

Trapani, Joseph A.

Smyth, Mark J.

机构：

[1] Peter MacCallum Canc Ctr, Canc Immunol Program, East Melbourne, Vic, Australia

[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic, Australia

[3] Univ Melbourne, Dept Genet, Parkville, Vic, Australia

[4] Univ Melbourne, Dept Pathol, Parkville, Vic, Australia

来源：

CURRENT OPINION IN IMMUNOLOGY | 2007年 / 19卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.coi.2007.04.007

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent progress has been made in discovering structure/ function relationships of the cytotoxic lymphocyte pore-forming protein - perforin - and its role in immune regulation. Long recognized as a key component of the granule exocytosis mechanism of lymphocyte-mediated apoptosis and in host defence against a variety of pathogens and tumors, more recent attention has focused upon mutations of the perforin gene in some patients with hemophagocytic lymphohistiocytosis. This clinical picture has prompted further work to uncover the molecular structure of perforin and to define its precise role in immune regulation and immunopathology.

引用

收藏

页码：339 / 347

页数：9

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