Experimental validation of proton transverse relaxivity models for superparamagnetic nanoparticle MRI contrast agents

被引：81

作者：

Carroll, Matthew R. J. ^{[1
]}

Woodward, Robert C. ^{[1
]}

House, Michael J. ^{[1
]}

Teoh, Wey Yang ^{[2
]}

Amal, Rose ^{[2
]}

Hanley, Tracey L. ^{[3
]}

St Pierre, Timothy G. ^{[1
]}

机构：

[1] Univ Western Australia, Sch Phys, Ctr Strateg Nanofabricat, Crawley, WA 6009, Australia

[2] Univ New S Wales, ARC, Ctr Excellence Funct Nanomat, Sch Chem Engn & Ind Chem, Sydney, NSW 2052, Australia

[3] Australian Nucl Sci & Technol Org, Bragg Inst, Lucas Heights, NSW 2234, Australia

来源：

NANOTECHNOLOGY | 2010年 / 21卷 / 03期

基金：

澳大利亚研究理事会;

关键词：

IRON-OXIDE NANOPARTICLES; MAGNETIC-PROPERTIES; PARTICLE-SIZE; RELAXATION; TISSUES;

D O I：

10.1088/0957-4484/21/3/035103

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Analytical models of proton transverse relaxation rate enhancement by magnetic nanoparticles were tested by making measurements on model experimental systems in a field of 1.4 T. Proton relaxivities were measured for five aqueous suspensions of iron oxide (maghemite) nanoparticles with nominal mean particle sizes of 6, 8, 10, 11, and 13 nm. Proton relaxivity increased with mean particle size ranging from 13 s(-1) mM Fe-1 for the 6 nm sample, up to 254 s(-1) mM Fe-1 for the 13 nm sample. A strong correlation between the measured and predicted values of the relaxivity was observed, with the predicted values being consistently higher than the measured values. The results indicate that the models give a reasonable agreement with experimental results and hence can be used as the basis for the design of new magnetic resonance imaging contrast and labelling agents.

引用

页数：7

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