Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

被引：314

作者：

Chaturvedi, Devdutt ^{[1
]}

Goswami, Abhishek ^{[1
]}

Saikia, Partha Pratim ^{[1
]}

Barua, Nabin C. ^{[1
]}

Rao, Paruchuri G. ^{[1
]}

机构：

[1] NE Inst Sci & Technol, Nat Prod Chem Div, Jorhat 785006, Assam, India

来源：

CHEMICAL SOCIETY REVIEWS | 2010年 / 39卷 / 02期

关键词：

MALARIA-INFECTED MICE; TRIOXANE DIMERS; IMMUNOSUPPRESSIVE ACTIVITY; ANTITUMOR ACTIVITIES; POTENT ANTIMALARIAL; HIGH-STABILITY; IN-VITRO; ANALOGS; EFFICACY; DIHYDROARTEMISININ;

D O I：

10.1039/b816679j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this tutorial review, an effort towards presentation of a comprehensive account of the recent developments on various kinds of artemisinin derivatives including artemisinin dimers, trimers and tetramers has been made and their efficacy towards malaria parasites and different cancer cells lines was compared with that of artemisinins, and various other anti-malarial and anti-cancer drugs. It is expected that this review will provide first-hand information on artemisinin chemistry to organic/medicinal chemists, and pharmacologists working on anticancer and anti-malarial drug development.

引用

页码：435 / 454

页数：20

共 63 条

[1] SYNTHESIS AND ANTIMALARIAL ACTIVITY OF SOME 9-SUBSTITUTED ARTEMISININ DERIVATIVES [J].

ACTON, N ;

KARLE, JM ;

MILLER, RE .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (17) :2552-2557

[2] ARTEMISITENE, A NEW SESQUITERPENE LACTONE ENDOPEROXIDE FROM ARTEMISIA-ANNUA [J].

ACTON, N ;

KLAYMAN, DL .

PLANTA MEDICA, 1985, 51 (05) :441-442

[3] Biological mechanisms of action of novel C-10 non-acetal trioxane dimers in prostate cancer cell lines [J].

Alagbala, Adebusola A. ;

McRiner, Andrew J. ;

Borstnik, Kristina ;

Labonte, Tanzina ;

Chang, Wonsuk ;

D'Angelo, John G. ;

Posner, Gary H. ;

Foster, Barbara A. .

JOURNAL OF MEDICINAL CHEMISTRY, 2006, 49 (26) :7836-7842

[4] STRUCTURE-ACTIVITY-RELATIONSHIPS OF THE ANTIMALARIAL AGENT ARTEMISININ .1. SYNTHESIS AND COMPARATIVE MOLECULAR-FIELD ANALYSIS OF C-9 ANALOGS OF ARTEMISININ AND 10-DEOXOARTEMISININ [J].

AVERY, MA ;

GAO, FG ;

CHONG, WKM ;

MEHROTRA, S ;

MILHOUS, WK .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (26) :4264-4275

[5] Structure-activity relationships of the antimalarial agent artemisinin .5. Analogs of 10-deoxoartemisinin substituted at C-3 and C-9 [J].

Avery, MA ;

Mehrotra, S ;

Johnson, TL ;

Bonk, JD ;

Vroman, JA ;

Miller, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (21) :4149-4155

[6]

AVERY MA, 1999, ADV MED CH, V4, P125

[7] Stereochemistry-dependent cytotoxicity of some artemisinin derivatives [J].

Beekman, AC ;

Barentsen, ARW ;

Woerdenbag, HJ ;

VanUden, W ;

Pras, N ;

Konings, AWT ;

ElFeraly, FS ;

Galal, AM ;

Wikstrom, HV .

JOURNAL OF NATURAL PRODUCTS, 1997, 60 (04) :325-330

[8] Recent developments with 1,2,4-trioxane-type artemisinin analogues [J].

Bez, G ;

Kalita, B ;

Sarmah, P ;

Barua, NC ;

Dutta, DK .

CURRENT ORGANIC CHEMISTRY, 2003, 7 (12) :1231-1255

[9]

Bhattacharya AK, 1999, HETEROCYCLES, V51, P1681

[10] NATURALLY-OCCURRING CADINENES [J].

BORDOLOI, M ;

SHUKLA, VS ;

NATH, SC ;

SHARMA, RP .

PHYTOCHEMISTRY, 1989, 28 (08) :2007-2037

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