Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

被引：314

作者：

Chaturvedi, Devdutt ^{[1
]}

Goswami, Abhishek ^{[1
]}

Saikia, Partha Pratim ^{[1
]}

Barua, Nabin C. ^{[1
]}

Rao, Paruchuri G. ^{[1
]}

机构：

[1] NE Inst Sci & Technol, Nat Prod Chem Div, Jorhat 785006, Assam, India

来源：

CHEMICAL SOCIETY REVIEWS | 2010年 / 39卷 / 02期

关键词：

MALARIA-INFECTED MICE; TRIOXANE DIMERS; IMMUNOSUPPRESSIVE ACTIVITY; ANTITUMOR ACTIVITIES; POTENT ANTIMALARIAL; HIGH-STABILITY; IN-VITRO; ANALOGS; EFFICACY; DIHYDROARTEMISININ;

D O I：

10.1039/b816679j

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this tutorial review, an effort towards presentation of a comprehensive account of the recent developments on various kinds of artemisinin derivatives including artemisinin dimers, trimers and tetramers has been made and their efficacy towards malaria parasites and different cancer cells lines was compared with that of artemisinins, and various other anti-malarial and anti-cancer drugs. It is expected that this review will provide first-hand information on artemisinin chemistry to organic/medicinal chemists, and pharmacologists working on anticancer and anti-malarial drug development.

引用

页码：435 / 454

页数：20

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