Phosphaadamantanes as ligands for palladium catalyzed cross-coupling chemistry:: Library synthesis, characterization, and screening in the Suzuki coupling of alkyl halides and tosylates containing β-hydrogens with boronic acids and alkylboranes

被引：82

作者：

Brenstrum, T

Gerristma, DA

Adjabeng, GM

Frampton, CS

Britten, J

Robertson, AJ

McNulty, J

Capretta, A ^{[1
]}

机构：

[1] McMaster Univ, Dept Chem, Hamilton, ON L8S 4M1, Canada

[2] Bruker Nonius BV, NL-2612 HL Delft, Netherlands

[3] Cytec Canada Inc, Niagara Falls, ON L2E 6T4, Canada

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2004年 / 69卷 / 22期

关键词：

D O I：

10.1021/jo048875+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A 15-member library of phosphaadamantane ligands has been prepared via P-arylation of 1,3,5,7-tetramethyl-2,4,8-trioxa-6-phosphaadamantane. Screening of this tertiary phosphine collection has allowed for the rapid determination of the most suitable ligand, specifically 1,3,5,7-tetramethyl-6-(2,4-dimethoxyphenyl)-2,4,8-trioxa-6-phosphaadamantane, for facilitating Suzuki-type couplings of alkyl halides or tosylates containing beta-hydrogens with either boronic acids or alkylboranes.

引用

页码：7635 / 7639

页数：5

共 38 条

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