A role for Caenorhabditis elegans chromatin-associated protein HIM-17 in the proliferation vs. meiotic entry decision

被引：21

作者：

Bessler, Jessica B.

Reddy, Kirthi C.

Hayashi, Michiko

Hodgkin, Jonathan

Villeneuve, Anne M.

机构：

[1] Stanford Univ, Dept Dev Biol, Sch Med, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Genet, Sch Med, Stanford, CA 94305 USA

[3] Univ Oxford, Dept Biochem, Genet Unit, Oxford OX1 3QU, England

来源：

GENETICS | 2007年 / 175卷 / 04期

基金：

英国医学研究理事会;

关键词：

C-ELEGANS; GERM-LINE; GENETIC-ANALYSIS; CHROMOSOME SYNAPSIS; SIGNALING PATHWAY; CHIASMA FORMATION; CELL-INTERACTIONS; RECOMBINATION; PROPHASE; MUTANTS;

D O I：

10.1534/genetics.107.070987

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Chromatin-associated protein HIM-17 was previously shown to function in the chromosomal events of meiotic prophase. Here we report an additional role for HIM-17 in regulating the balance between germ cell proliferation and meiotic development. A cryptic function for HIM-17 in promoting meiotic entry and/or inhibiting proliferation was revealed by defects in germline organization in him-17 mutants grown at high temperature (25 degrees) and by a synthetic tumorous germline phenotype in glp-1(ar202); him-17 mutants at 15 degrees.

引用

页码：2029 / 2037

页数：9

共 37 条

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