Differential somato-dendritic localization of TrkA, TrkB, TrkC and p75 mRNAs in vivo

被引：9

作者：

Tongiorgi, E

Armellin, M

Cattaneo, A

机构：

[1] Univ Trieste, Dept Biol, BRAIN Ctr Neurosci, I-34127 Trieste, Italy

[2] SISSA, I-34014 Trieste, Italy

来源：

NEUROREPORT | 2000年 / 11卷 / 14期

关键词：

dendritic mRNA; diagonal band; neurotrophin receptors; septum; targeting; ventral pallidum;

D O I：

10.1097/00001756-200009280-00043

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

TrkB mRNA was shown to be localized in the somatodendritic compartment in vitro but no data are currently available on the subcellular distribution of the neurotrophin receptors mRNAs in vivo. Here we describe the subcellular distribution of TrkA, TrkB, TrkC and p75 mRNAs in the adult rat basal forebrain. We find that TrkA, TrkC and p75 mRNAs are restricted to the cell soma but in addition, p75 mRNA labelling extends in average for 8 mu m within the proximal dendrites of 34% of the labelled neurons. TrkB mRNA has a somatodendritic distribution in 95% of the labelled neurons reaching variable distances in different neurons (23-84.5 mu m) and forebrain regions (mean: 40, 51 and 55 mu m for diagonal band, septum and ventral pallidum). NeuroReport 11:3265-3268 (C) 2000 Lippincott Williams & Wilkins.

引用

收藏

页码：3265 / 3268

页数：4

相关论文

共 23 条

[1] Dendritic and postsynaptic protein synthetic machinery [J].

Gardiol, A ;

Racca, C ;

Triller, A .

JOURNAL OF NEUROSCIENCE, 1999, 19 (01) :168-179

[2] IN-SITU HYBRIDIZATION DETECTION OF TRKA MESSENGER-RNA IN BRAIN - DISTRIBUTION, COLOCALIZATION WITH P75(NGFR) AND UP-REGULATION BY NERVE GROWTH-FACTOR [J].

GIBBS, RB ;

PFAFF, DW .

JOURNAL OF COMPARATIVE NEUROLOGY, 1994, 341 (03) :324-339

[3]

HOLZMAN DM, 1992, NEURON, V9, P465

[4] LOCALIZATION OF NERVE GROWTH-FACTOR RECEPTOR MESSENGER-RNA AND PROTEIN IN THE ADULT-RAT BRAIN [J].

KOH, S ;

OYLER, GA ;

HIGGINS, GA .

EXPERIMENTAL NEUROLOGY, 1989, 106 (03) :209-221

[5] COEXPRESSION OF NEUROTROPHINS AND THEIR RECEPTORS IN NEURONS OF THE CENTRAL-NERVOUS-SYSTEM [J].

KOKAIA, Z ;

BENGZON, J ;

METSIS, M ;

KOKAIA, M ;

PERSSON, H ;

LINDVALL, O .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (14) :6711-6715

[6] Dendritic localization of mRNAs [J].

Kuhl, D ;

Skehel, P .

CURRENT OPINION IN NEUROBIOLOGY, 1998, 8 (05) :600-606

[7] SOMATODENDRITIC EXPRESSION OF AN IMMEDIATE-EARLY GENE IS REGULATED BY SYNAPTIC ACTIVITY [J].

LINK, W ;

KONIETZKO, U ;

KAUSELMANN, G ;

KRUG, M ;

SCHWANKE, B ;

FREY, U ;

KUHL, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (12) :5734-5738

[8] ARC, A GROWTH-FACTOR AND ACTIVITY-REGULATED GENE, ENCODES A NOVEL CYTOSKELETON-ASSOCIATED PROTEIN THAT IS ENRICHED IN NEURONAL DENDRITES [J].

LYFORD, GL ;

YAMAGATA, K ;

KAUFMANN, WE ;

BARNES, CA ;

SANDERS, LK ;

COPELAND, NG ;

GILBERT, DJ ;

JENKINS, NA ;

LANAHAN, AA ;

WORLEY, PF .

NEURON, 1995, 14 (02) :433-445

[9]

Martone ME, 1996, J NEUROSCI, V16, P7437

[10] MOLECULAR-CLONING OF RAT TRKC AND DISTRIBUTION OF CELLS EXPRESSING MESSENGER-RNAS FOR MEMBERS OF THE TRK FAMILY IN THE RAT CENTRAL-NERVOUS-SYSTEM [J].

MERLIO, JP ;

ERNFORS, P ;

JABER, M ;

PERSSON, H .

NEUROSCIENCE, 1992, 51 (03) :513-532