Role of the Host Defense System and Intestinal Microbial Flora in the Pathogenesis of Necrotizing Enterocolitis

被引：50

作者：

Emami, Claudia N. ^{[1
]}

Petrosyan, Mikael ^{[1
]}

Giuliani, Stefano ^{[1
]}

Williams, Monica ^{[1
]}

Hunter, Catherine ^{[1
]}

Prasadarao, Nemani V. ^{[2
,3
]}

Ford, Henri R. ^{[1
]}

机构：

[1] Univ So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Dept Surg, Los Angeles, CA 90027 USA

[2] Univ So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Dept Pediat Surg, Los Angeles, CA 90027 USA

[3] Univ So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Div Infect Dis, Los Angeles, CA 90027 USA

来源：

SURGICAL INFECTIONS | 2009年 / 10卷 / 05期

关键词：

BIRTH-WEIGHT INFANTS; NEONATAL-RESEARCH-NETWORK; TIGHT JUNCTION PROTEINS; EPITHELIAL-CELL INJURY; GUT BARRIER FAILURE; DELTA-T-CELLS; NITRIC-OXIDE; ENTEROBACTER-SAKAZAKII; GAMMA-DELTA; HUMAN-MILK;

D O I：

10.1089/sur.2009.054

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Background: Necrotizing enterocolitis (NEC) is a devastating disease that affects primarily the intestine of premature infants. Despite recent advances in neonatology, NEC remains a major cause of morbidity and mortality in neonates. Neonatal mucosal defenses and adherence of bacterial pathogens may play an important role in the pathogenesis of NEC. Methods: Review and synthesis of pertinent literature. Results: Putative factors that have been implicated in the pathogenesis of NEC include abnormal patterns of gut colonization by bacteria, immaturity of the host immune system and mucosal defense mechanisms, intestinal ischemia, formula feeding, and loss of intestinal epithelial barrier integrity. Conclusion: Host defenses and intestinal microbial ecology are believed to play important roles in the pathogenesis of NEC. Commensal bacteria and probiotic therapy may be of therapeutic utility in the maintenance of the gut epithelial barrier.

引用

页码：407 / 417

页数：11

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