Blood on the tracks:: a simple twist of fate?

被引:13
作者
Meletis, K [1 ]
Frisén, J [1 ]
机构
[1] Karolinska Inst, Med Nobel Inst, Dept Cell & Mol Biol, SE-17177 Stockholm, Sweden
关键词
D O I
10.1016/S0166-2236(03)00125-5
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Recent studies suggest that non-neural cells can generate neurons in mice and humans. There is no lack of excitement about these results: they challenge our view of cellular differentiation and the prospect of being able to generate neurons from, for example, blood is very attractive. But is it too good to be true?
引用
收藏
页码:292 / 296
页数:5
相关论文
共 63 条
[11]  
Castro RF, 2003, SCIENCE, V299
[12]   NRSF/REST is required in vivo for repression of multiple neuronal target genes during embryogenesis [J].
Chen, ZF ;
Paquette, AJ ;
Anderson, DJ .
NATURE GENETICS, 1998, 20 (02) :136-142
[13]   Differentiation potential of adult stem cells [J].
Clarke, D ;
Frisén, J .
CURRENT OPINION IN GENETICS & DEVELOPMENT, 2001, 11 (05) :575-580
[14]   Role of mesenchymal stem cells in hematopoietic stem cell transplantation [J].
Devine, SM ;
Hoffman, R .
CURRENT OPINION IN HEMATOLOGY, 2000, 7 (06) :358-363
[15]   Transcriptional repression by Pax5 (BSAP) through interaction with corepressors of the Groucho family [J].
Eberhard, D ;
Jiménez, G ;
Heavey, B ;
Busslinger, M .
EMBO JOURNAL, 2000, 19 (10) :2292-2303
[16]   Hematopoietic cells differentiate into both microglia and macroglia in the brains of adult mice [J].
Eglitis, MA ;
Mezey, E .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :4080-4085
[18]   Transdifferentiation and nuclear reprogramming in hematopoietic development and neoplasia [J].
French, SW ;
Hoyer, KK ;
Shen, RR ;
Teitell, MA .
IMMUNOLOGICAL REVIEWS, 2002, 187 :22-39
[19]   Stem cell plasticity? [J].
Frisén, J .
NEURON, 2002, 35 (03) :415-418
[20]   Reprogramming fibroblasts to express T-cell functions using cell extracts [J].
Håkelien, AM ;
Landsverk, HB ;
Robl, JM ;
Skålhegg, BS ;
Collas, P .
NATURE BIOTECHNOLOGY, 2002, 20 (05) :460-466