We have reported that serum IL-6 level was related with the degree of anemia in monkey collagen-induced arthritis (CIA). In this study, we examined whether IL-6 blockade ameliorated an anemia in monkey CIA. CIA was induced by twice immunization of bovine type II collagen with adjuvant. When anemia became evident, anti-IL-6 receptor antibody, tocilizumab was intravenously injected once a week for 4 weeks. Controls received PBS in a same manner. Hematological and biochemical parameters were measured regularly and serum hepcidin-25 levels were measured by SELDI-TOF mass spectrometry. Moreover, hepcidin mRNA induction in Hep3B cells by serum from arthritic monkeys was examined by real-time PCR. Administration of tocilizumab rapidly decreased CRP levels and improved iron-deficient anemia within 1 week. Tocilizumab induced rapid but transient reduction in serum hepcidin-25. Hepcidin mRNA expression was more potently induced by serum from arthritic monkey and this was inhibited by the addition of tocilizumab. Blockade of IL-6 signaling rapidly improved anemia in monkey arthritis via the inhibition of IL-6-induced hepcidin production.
机构:
Med Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Hietzing Hosp, Dept Med 2, Vienna, AustriaMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Smolen, Josef S.
Beaulieu, Andre
论文数: 0引用数: 0
h-index: 0
机构:
Univ Laval, Fac Med, Laval, PQ, CanadaMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Beaulieu, Andre
Rubbert-Roth, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cologne, Med Clin 1, Cologne, GermanyMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Rubbert-Roth, Andrea
Ramos-Remus, Cesar
论文数: 0引用数: 0
h-index: 0
机构:
Res Unit Chron Dis, Guadalajara, Jalisco, MexicoMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Ramos-Remus, Cesar
Rovensky, Josef
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Rheumat Dis, Piestany, SlovakiaMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Rovensky, Josef
Alecock, Emma
论文数: 0引用数: 0
h-index: 0
机构:
Roche Prod Ltd, Welwyn Garden City AL7 3AY, Herts, EnglandMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Alecock, Emma
Woodworth, Thasia
论文数: 0引用数: 0
h-index: 0
机构:
Roche Prod Ltd, Welwyn Garden City AL7 3AY, Herts, EnglandMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Woodworth, Thasia
Alten, Rieke
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Berlin, Dept Internal Med 2, Schlosspk Clin, Berlin, GermanyMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
机构:
Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, JapanKanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Tomosugi, Naohisa
Kawabata, Hiroshi
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h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Kawabata, Hiroshi
Wakatabe, Rumi
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h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Wakatabe, Rumi
Higuchi, Masato
论文数: 0引用数: 0
h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Higuchi, Masato
Yamaya, Hideki
论文数: 0引用数: 0
h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Yamaya, Hideki
Umehara, Hisanori
论文数: 0引用数: 0
h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Umehara, Hisanori
Ishikawa, Isao
论文数: 0引用数: 0
h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
机构:
Med Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Hietzing Hosp, Dept Med 2, Vienna, AustriaMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Smolen, Josef S.
Beaulieu, Andre
论文数: 0引用数: 0
h-index: 0
机构:
Univ Laval, Fac Med, Laval, PQ, CanadaMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Beaulieu, Andre
Rubbert-Roth, Andrea
论文数: 0引用数: 0
h-index: 0
机构:
Univ Cologne, Med Clin 1, Cologne, GermanyMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Rubbert-Roth, Andrea
Ramos-Remus, Cesar
论文数: 0引用数: 0
h-index: 0
机构:
Res Unit Chron Dis, Guadalajara, Jalisco, MexicoMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Ramos-Remus, Cesar
Rovensky, Josef
论文数: 0引用数: 0
h-index: 0
机构:
Natl Inst Rheumat Dis, Piestany, SlovakiaMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Rovensky, Josef
Alecock, Emma
论文数: 0引用数: 0
h-index: 0
机构:
Roche Prod Ltd, Welwyn Garden City AL7 3AY, Herts, EnglandMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Alecock, Emma
Woodworth, Thasia
论文数: 0引用数: 0
h-index: 0
机构:
Roche Prod Ltd, Welwyn Garden City AL7 3AY, Herts, EnglandMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
Woodworth, Thasia
Alten, Rieke
论文数: 0引用数: 0
h-index: 0
机构:
Univ Med Berlin, Dept Internal Med 2, Schlosspk Clin, Berlin, GermanyMed Univ Vienna, Div Rheumatol, Dept Internal Med 3, Vienna, Austria
机构:
Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, JapanKanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Tomosugi, Naohisa
Kawabata, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Kawabata, Hiroshi
Wakatabe, Rumi
论文数: 0引用数: 0
h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Wakatabe, Rumi
Higuchi, Masato
论文数: 0引用数: 0
h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Higuchi, Masato
Yamaya, Hideki
论文数: 0引用数: 0
h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Yamaya, Hideki
Umehara, Hisanori
论文数: 0引用数: 0
h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan
Umehara, Hisanori
Ishikawa, Isao
论文数: 0引用数: 0
h-index: 0
机构:Kanazawa Med Univ, Div Nephrol, Dept Internal Med, Kahoku, Ishikawa 9200293, Japan