Mutant prevention concentration as a measure of antibiotic potency:: Studies with clinical isolates of Mycobacterium tuberculosis

被引：105

作者：

Dong, YZ ^{[1
]}

Zhao, XL ^{[1
]}

Kreiswirth, BN ^{[1
]}

Drlica, K ^{[1
]}

机构：

[1] Publ Hlth Res Inst, New York, NY 10016 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2000年 / 44卷 / 09期

关键词：

D O I：

10.1128/AAC.44.9.2581-2584.2000

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The mutant prevention concentration (MPC) of a C-8-methoxy fluoroquinolone exhibited a narrow distribution for 14 genetically diverse clinical isolates of Mycobacterium tuberculosis, indicating that results from single-isolate studies are likely to be representative. When one isolate was challenged with a variety of antituberculosis agents, C-8-methoxy fluoroquinolones were exceptional in having MPCs below the maximum concentration attained in serum by use of commonly recommended doses.

引用

页码：2581 / 2584

页数：4

共 24 条

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