Elevated corticosterone in the amygdala leads to persistant increases in anxiety-like behavior and pain sensitivity

被引：62

作者：

Myers, Brent ^{[1
]}

Meerveld, Beverley Greenwood-Van ^{[1
]}

机构：

[1] Univ Oklahoma, Hlth Sci Ctr, Oklahoma Ctr Neurosci, VA Med Ctr, Oklahoma City, OK USA

来源：

BEHAVIOURAL BRAIN RESEARCH | 2010年 / 214卷 / 02期

关键词：

Stress; Corticotropin releasing factor; Amygdala; Visceral sensitivity; Somatic sensitivity; Glucocorticoid; RECEPTOR-MEDIATED MECHANISMS; IRRITABLE-BOWEL-SYNDROME; FACTOR MESSENGER-RNA; STRIA TERMINALIS; BED NUCLEUS; GENE-EXPRESSION; RAT; DYSREGULATION; STRESS; IMMUNOREACTIVITY;

D O I：

10.1016/j.bbr.2010.05.049

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学（含古人类学）];

摘要：

Corticosterone (CORT) localized to the amygdala induces anxiety-like behavior coupled with increased behavioral responses to visceral and somatic stimuli. In the current study, we investigated the long-term consequences of briefly exposing the amygdala to elevated levels of CORT with the hypothesis that modulation of the amygdala with CORT results in persistent increases in anxiety-like behavior and viscerosomatic sensitivity. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：465 / 469

页数：5

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