Regulation of bone resorption and formation by purines and pyrimidines

被引：106

作者：

Hoebertz, A

Arnett, TR

Burnstock, G

机构：

[1] Royal Free & Univ Coll, Autonom Neurosci Inst, Sch Med, London NW3 2PF, England

[2] Res Inst Mol Biol, A-1030 Vienna, Austria

[3] UCL, Dept Anat & Dev Biol, London WC1E 6BT, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2003年 / 24卷 / 06期

关键词：

D O I：

10.1016/S0165-6147(03)00123-8

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Growing evidence suggests that extracellular nucleotides, signalling through P2 receptors, might play important roles in the regulation of bone and cartilage metabolism. ATP and other nucleotides can exert impressive stimulatory effects on the formation and activity of osteoclasts (bone-resorbing cells) in addition to inhibiting bone formation by osteoblasts. In this review, the current understanding of the actions of nucleotides on skeletal cells and the probable receptor subtypes involved are discussed.

引用

收藏

页码：290 / 297

页数：8

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