AIDS Progression Is Associated with the Emergence of IL-17-Producing Cells Early After Simian Immunodeficiency Virus Infection

被引:47
作者
Campillo-Gimenez, Laure [1 ]
Cumont, Marie-Christine
Fay, Michele [2 ]
Kared, Hassen [1 ]
Monceaux, Valerie
Diop, Ousmane [5 ]
Mueller-Trutwin, Michaela
Hurtrel, Bruno
Levy, Yves [1 ]
Zaunders, John [6 ]
Dy, Michel [3 ]
Leite-de-Moraes, Maria C. [3 ]
Elbim, Carole [1 ,4 ]
Estaquier, Jerome [1 ]
机构
[1] Hop Henri Mondor, AP HP, INSERM, U955,Fac Med Creteil, F-94010 Creteil, France
[2] Univ Paris 07, Fac Med, F-75221 Paris 05, France
[3] Hop NeckerParis, Fac Med Rene Descartes, UMR 8147, Paris 15, France
[4] Univ Paris 06, Ctr Rech Cordeliers, UMR S 872, Paris, France
[5] Inst Pasteur, Dakar, Senegal
[6] St Vincents Hosp, Ctr Immunol, Darlinghurst, NSW 2010, Australia
关键词
GROWTH-FACTOR-BETA; KILLER T-CELLS; ROR-GAMMA-T; NKT CELLS; TGF-BETA; SIV INFECTION; I INTERFERON; LYMPH-NODES; MICROBIAL TRANSLOCATION; LENTIVIRAL INFECTIONS;
D O I
10.4049/jimmunol.0902316
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
IL-17 is a potent effector cytokine involved in inflammatory response and antimicrobial defense. We report that SIV infection of rhesus macaques (RMs) results in the emergence of IL-17-expressing cells during the acute phase. This subpopulation appears at day 14 postinfection concomitantly with an increase in TGF-beta and IL-18 expression. This subset, which exhibits phenotypic markers of NK T cells (NKT), rather than Th17 CD4 cells, persists during the chronic phase and is higher in noncontrollers SIV-infected RMs compared with controllers SIV-infected RMs. In contrast, in the nonpathogenic model of SIVagm infection of African green monkeys, no change in the level of IL-17-expressing cells is observed in lymphoid organs. Consistent with the emergence of TGF-beta and IL-18 during the acute phase in SIV-infected RMs, but not in SIV-infected African green monkeys, we demonstrate that in vitro TGF-beta and IL-18 induce the differentiation and expansion of IL-17(+)NKT(+). Altogether, these results demonstrate that IL-17-producing NKT are associated with the pathogenesis of SIV in RMs and suggest that TGF-beta and IL-18 play a role in their development. The Journal of Immunology, 2010, 184: 984-992.
引用
收藏
页码:984 / 992
页数:9
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