Differential expression of CD2 on neoplastic mast cells in patients with systemic mast cell disease with and without an associated clonal haematological disorder

被引：18

作者：

Pardanani, A

Kimlinger, TK

Reeder, TL

Li, CY

Tefferi, A

机构：

[1] Mayo Clin & Mayo Fdn, Div Hematol & Internal Med, Rochester, MN 55905 USA

[2] Mayo Clin & Mayo Fdn, Dept Lab Med & Pathol, Rochester, MN 55905 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2003年 / 120卷 / 04期

关键词：

CD2; expression; mast cells; systemic mast cell disease;

D O I：

10.1046/j.1365-2141.2003.04125.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, aberrant coexpression of CD2 and CD25 has been reported to reliably distinguish neoplastic mast cells from normal or so-called reactive mast cells. Such expression is included in the consensus diagnostic criteria for systemic mast cell disease (SMCD). In our study of patients with SMCD, we found CD2 expression to be more prevalent on mast cells from patients without an associated haematological disorder (P = 0.04). Furthermore, no correlation was found between mast cell CD2 expression and other clinicopathological features in these patients.

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收藏

页码：691 / 694

页数：4

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