The P2X7 Receptor in Infection and Inflammation

被引：1103

作者：

Di Virgilio, Francesco ^{[1
]}

Dal Ben, Diego ^{[2
]}

Sarti, Alba Clara ^{[1
]}

Giuliani, Anna Lisa ^{[1
]}

Falzoni, Simonetta ^{[1
]}

机构：

[1] Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Italy

[2] Univ Camerino, Sch Pharm, Camerino, Italy

来源：

IMMUNITY | 2017年 / 47卷 / 01期

关键词：

IMMUNOGENIC CELL-DEATH; HUMAN DENDRITIC CELLS; GAIN-OF-FUNCTION; P2X(7) RECEPTOR; EXTRACELLULAR ATP; NLRP3; INFLAMMASOME; PURINERGIC RECEPTORS; NUCLEOTIDE RECEPTOR; PHOSPHOLIPASE-D; RHEUMATOID-ARTHRITIS;

D O I：

10.1016/j.immuni.2017.06.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

A denosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors named P2 receptors (P2Rs). The P2R most involved in inflammation and immunity is the P2X7 receptor (P2X7R), expressed by virtually all cells of innate and adaptive immunity. P2X7R mediates NLRP3 inflammasome activation, cytokine and chemokine release, T lymphocyte survival and differentiation, transcription factor activation, and cell death. Ten human P2RX7 gene splice variants and several SNPs that produce complex haplotypes are known. The P2X7R is a potent stimulant of inflammation and immunity and a promoter of cancer cell growth. This makes P2X7R an appealing target for anti-inflammatory and anti-cancer therapy. However, an in-depth knowledge of its structure and of the associated signal transduction mechanisms is needed for an effective therapeutic development.

引用

收藏

页码：15 / 31

页数：17

相关论文

共 192 条

[1]

A Truncation Variant of the Cation Channel P2RX5 Is Upregulated during T Cell Activation [J].

Abramowski, Pierre ;

Ogrodowczyk, Christoph ;

Martin, Roland ;

Pongs, Olaf .

PLOS ONE, 2014, 9 (09)

[2]

Basal activation of the P2X7 ATP receptor elevates mitochondrial calcium and potential, increases cellular ATP levels, and promotes serum-independent growth [J].

Adinolfi, E ;

Callegari, MG ;

Ferrari, D ;

Bolognesi, C ;

Minelli, M ;

Wieckowski, MR ;

Pinton, P ;

Rizzuto, R ;

Di Virgilio, F .

MOLECULAR BIOLOGY OF THE CELL, 2005, 16 (07) :3260-3272

[3]

Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7 [J].

Adinolfi, Elena ;

Capece, Marina ;

Franceschini, Alessia ;

Falzoni, Simonetta ;

Giuliani, Anna L. ;

Rotondo, Alessandra ;

Sarti, Alba C. ;

Bonora, Massimo ;

Syberg, Susanne ;

Corigliano, Domenica ;

Pinton, Paolo ;

Jorgensen, Niklas R. ;

Abelli, Luigi ;

Emionite, Laura ;

Raffaghello, Lizzia ;

Pistoia, Vito ;

Di Virgilio, Francesco .

CANCER RESEARCH, 2015, 75 (04) :635-644

[4]

Trophic activity of a naturally occurring truncated isoform of the P2X7 receptor [J].

Adinolfi, Elena ;

Cirillo, Maria ;

Woltersdorf, Ronja ;

Falzoni, Simonetta ;

Chiozzi, Paola ;

Pellegatti, Patrizia ;

Callegari, Maria Giulia ;

Sandona, Doriana ;

Markwardt, Fritz ;

Schmalzing, Guenther ;

Di Virgilio, Francesco .

FASEB JOURNAL, 2010, 24 (09) :3393-3404

[5]

Is pannexin the pore associated with the P2X7 receptor? [J].

Alberto, A. V. P. ;

Faria, R. X. ;

Couto, C. G. C. ;

Ferreira, L. G. B. ;

Souza, C. A. M. ;

Teixeira, P. C. N. ;

Froes, M. M. ;

Alves, L. A. .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2013, 386 (09) :775-787

[6]

Anthrax Toxin Induces Macrophage Death by p38 MAPK Inhibition but Leads to Inflammasome Activation via ATP Leakage [J].

Ali, Syed Raza ;

Timmer, Anjuli M. ;

Bilgrami, Sameera ;

Park, Eek Joong ;

Eckmann, Lars ;

Nizet, Victor ;

Karin, Michael .

IMMUNITY, 2011, 35 (01) :34-44

[7]

Activation by P2X7 agonists of two phospholipases A2 (PLA2) in ductal cells of rat submandibular gland -: Coupling of the calcium-independent PLA2 with kallikrein secretion [J].

Alzola, E ;

Pérez-Etxebarria, A ;

Kabré, E ;

Fogarty, DJ ;

Métioui, M ;

Chaïb, N ;

Macarulla, JM ;

Matute, C ;

Dehaye, JP ;

Marino, A .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (46) :30208-30217

[8]

Pulmonary Infection with Hypervirulent Mycobacteria Reveals a Crucial Role for the P2X7 Receptor in Aggressive Forms of Tuberculosis [J].

Amaral, Eduardo P. ;

Ribeiro, Simone C. M. ;

Lanes, Veronica R. ;

Almeida, Fabricio M. ;

de Andrade, Marcelle R. M. ;

Barbosa Bomfim, Caio Cesar ;

Salles, Erika M. ;

Bortoluci, Karina R. ;

Coutinho-Silva, Robson ;

Hirata, Mario H. ;

Alvarez, Jose M. ;

Lasunskaia, Elena B. ;

D'Imperio-Lima, Maria Regina .

PLOS PATHOGENS, 2014, 10 (07)

[9]

The P2X7 receptor is a key modulator of the PI3K/GSK3β/VEGF signaling network: evidence in experimental neuroblastoma [J].

Amoroso, F. ;

Capece, M. ;

Rotondo, A. ;

Cangelosi, D. ;

Ferracin, M. ;

Franceschini, A. ;

Raffaghello, L. ;

Pistoia, V. ;

Varesio, L. ;

Adinolfi, E. .

ONCOGENE, 2015, 34 (41) :5240-5251

[10]

The P2X7 receptor is a key modulator of aerobic glycolysis [J].

Amoroso, F. ;

Falzoni, S. ;

Adinolfi, E. ;

Ferrari, D. ;

Di Virgilio, F. .

CELL DEATH & DISEASE, 2012, 3 :e370-e370

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