The P2X7 Receptor in Infection and Inflammation

被引：1103

作者：

Di Virgilio, Francesco ^{[1
]}

Dal Ben, Diego ^{[2
]}

Sarti, Alba Clara ^{[1
]}

Giuliani, Anna Lisa ^{[1
]}

Falzoni, Simonetta ^{[1
]}

机构：

[1] Univ Ferrara, Dept Morphol Surg & Expt Med, Ferrara, Italy

[2] Univ Camerino, Sch Pharm, Camerino, Italy

来源：

IMMUNITY | 2017年 / 47卷 / 01期

关键词：

IMMUNOGENIC CELL-DEATH; HUMAN DENDRITIC CELLS; GAIN-OF-FUNCTION; P2X(7) RECEPTOR; EXTRACELLULAR ATP; NLRP3; INFLAMMASOME; PURINERGIC RECEPTORS; NUCLEOTIDE RECEPTOR; PHOSPHOLIPASE-D; RHEUMATOID-ARTHRITIS;

D O I：

10.1016/j.immuni.2017.06.020

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

A denosine triphosphate (ATP) accumulates at sites of tissue injury and inflammation. Effects of extracellular ATP are mediated by plasma membrane receptors named P2 receptors (P2Rs). The P2R most involved in inflammation and immunity is the P2X7 receptor (P2X7R), expressed by virtually all cells of innate and adaptive immunity. P2X7R mediates NLRP3 inflammasome activation, cytokine and chemokine release, T lymphocyte survival and differentiation, transcription factor activation, and cell death. Ten human P2RX7 gene splice variants and several SNPs that produce complex haplotypes are known. The P2X7R is a potent stimulant of inflammation and immunity and a promoter of cancer cell growth. This makes P2X7R an appealing target for anti-inflammatory and anti-cancer therapy. However, an in-depth knowledge of its structure and of the associated signal transduction mechanisms is needed for an effective therapeutic development.

引用

页码：15 / 31

页数：17

共 192 条

[81]

A Glu-496 to Ala polymorphism leads to loss of function of the human P2X7 receptor [J].