A family of poly(U) polymerases

被引：116

作者：

Kwak, Jae Eun ^{[1
]}

Wickens, Marvin ^{[1
]}

机构：

[1] Univ Wisconsin, Dept Biochem, Madison, WI 53706 USA

来源：

RNA | 2007年 / 13卷 / 06期

关键词：

poly(U) polymerase; RNA modification; beta-nucleotidyl transferase; poly(A);

D O I：

10.1261/rna.514007

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The GLD-2 family of poly(A) polymerases add successive AMP monomers to the 39 end of specific RNAs, forming a poly(A) tail. Here, we identify a new group of GLD-2-related nucleotidyl transferases from Arabidopsis, Schizosaccharomyces pombe, Caenorhabditis elegans, and humans. Like GLD-2, these enzymes are template independent and add nucleotides to the 39 end of an RNA substrate. However, these new enzymes, which we refer to as poly(U) polymerases, add poly(U) rather than poly(A) to their RNA substrates.

引用

收藏

页码：860 / 867

页数：8

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