Penetration of enfuvirtide, tenofovir, efavirenz, and protease inhibitors in the genital tract of HIV-1-infected men

被引：91

作者：

Ghosn, J ^{[1
]}

Chaix, ML

Peytavin, G

Rey, E

Bresson, JL

Goujard, C

Katlama, C

Viard, JP

Tréluyer, JM

Rouzioux, C

机构：

[1] Univ Paris 05, EA 3620, MRT, Virol Lab, F-75270 Paris 06, France

[2] CHU Necker Enfants Malad, Dept Malad Infect, F-75730 Paris, France

[3] CHU Bichat, Lab Pharmacol Clin, Paris, France

[4] CHU St Vincent Paul, Lab Pharmacol Clin, Paris, France

[5] CHU Bicetre, Le Kremlin Bicetre, France

[6] CHU Pitie Salpetriere, Dept Malad Infect, Paris, France

来源：

AIDS | 2004年 / 18卷 / 14期

关键词：

D O I：

10.1097/00002030-200409240-00014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

One likely mechanism of virological failure is poor antiretroviral. drug diffusion in sites of viral replication such as the genital tract. We measured antiretroviral drug concentrations in blood and semen in 13 HIV-infected men failing treatment. Enfuvirtide did not cross the blood-testis barrier, whereas tenofovir accumulated in semen. Unlike indinavir, semen concentrations of lopinavir, amprenavir, saquinavir and efavirenz were ineffective. These are worrying findings, because suboptimal semen drug concentrations may enhance the risk of sexually transmitted drug-resistant HIV variants.

引用

页码：1958 / 1961

页数：4

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